神经系统疾病的干细胞治疗

Stem cell therapy for nervous system diseases

背景:干细胞具有自我更新和多向分化的生物学特性,在生理或病理情况下能维持组织器官内环境的稳定,近年被广泛用于再生医学的研究。目的:对神经系统疾病的干细胞治疗进展进行综述。方法:通过Pubmed数据库检索有关干细胞治疗神经系统疾病的相关文献。检索词为"stemcells、Nervous system diseases、therapy"。初检得到298篇文献,最终保留54篇符合标准的文献进行分析。结果与结论:经过近些年的研究,干细胞被认为是神经损伤和变性疾病的一个很有前景的治疗手段。通过干细胞的移植,取代受损的神经细胞,促进受损神经网络的恢复从而重建神经功能。

BACKGROUND： Stem cells have capacity of multipotential differentiation and self-renewal, which can stabilize internal environment under physical or pathophysical conditions. So stem cells have been considered as a useful tool in regenerative medicine.OBJECTIVE： To overview the advancement of the stem cells therapies on nervous system diseases.METHODS： A computer-based online search of PubMed databases was undertaken for the literature of stem cells therapies on nervous system diseases using the Key words of ＂stem cells, nervous system diseases, therapy＂. Totally 298 articles were collected initially, and finally 54 articles were included in result analysis.RESULTS AND CONCLUSION： Stem cells are currently considered promising candidates for therapies on nervous system injuries and neurodegenerative diseases. Stem cells transplantation can replace the damaged cells and reconstruct neural network, which can improve neural function.