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选择压力下乙型肝炎病毒变异的分子特征及其意义 被引量：9

Molecular characteristics of HBV variants under the selective pressure and its significance
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摘要 乙型肝炎病毒（HBV）具有高度变异的特性，疫苗、抗病毒药物、诊断试剂等多种选择压力对HBV变异产生作用。选择压力下HBV变异可能影响乙型肝炎发病机制、免疫接种效果、抗病毒疗效以及实验室检测，掌握HBV变异的分子特征，对于乙型肝炎防治具有重要意义。 Hepatitis B virus has a high degree of genetic variation. Multiple selection pressure, exerted by vaccine, antiviral drugs and diagnostic reagents, might favor certain mutations of HBV. HBV variation under the selective pressure may affect the pathogenesis of HBV-related liver disease, immunization effect, antiviral efficacy and laboratory tests. In this paper, we summarize the molecular characteristics and its significance of HBV variants, which will help us to manage hepatitis B.
作者 陈瑜
机构地区 浙江大学医学院附属第一医院检验科传染病诊治国家重点实验室
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2012年第2期122-125,共4页 Chinese Journal of Laboratory Medicine
关键词 肝炎病毒 乙型 变异(遗传学) Hepatitis B virus Variation（genetics）
分类号 R51 [医药卫生—内科学]
  • 相关文献

参考文献23

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共引文献12

同被引文献69

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引证文献9

二级引证文献19

中华检验医学杂志
2012年 第2期

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