摘要
乙型肝炎病毒(HBV)具有高度变异的特性,疫苗、抗病毒药物、诊断试剂等多种选择压力对HBV变异产生作用。选择压力下HBV变异可能影响乙型肝炎发病机制、免疫接种效果、抗病毒疗效以及实验室检测,掌握HBV变异的分子特征,对于乙型肝炎防治具有重要意义。
Hepatitis B virus has a high degree of genetic variation. Multiple selection pressure, exerted by vaccine, antiviral drugs and diagnostic reagents, might favor certain mutations of HBV. HBV variation under the selective pressure may affect the pathogenesis of HBV-related liver disease, immunization effect, antiviral efficacy and laboratory tests. In this paper, we summarize the molecular characteristics and its significance of HBV variants, which will help us to manage hepatitis B.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2012年第2期122-125,共4页
Chinese Journal of Laboratory Medicine