免疫炎性反应与2型糖尿病大血管病变的相关性分析

Association between immunological and inflammatory reactions and type 2 diabetic macrovasculardisease

目的观察免疫炎性反应标志物在2型糖尿病大血管病变患者的表达及相关性。方法收集本院住院治疗120例2型糖尿病患者及60例正常体检者的病史和临床生化资料，2型糖尿病患者根据有无大血管病变分成两组，单纯2型糖尿病组与2型糖尿病大血管病变组。ELISA法分别测定两组患者的免疫炎性反应标记物IL-1B、TNF-仅及Hs-CRP。分析免疫炎性反应与2型糖尿病大血管病变之间的关系。结果2型糖尿病大血管病变组患者血FBG、PPG、HbAlc、Hs-CRP及TNF-a水平[（9．86±1．79）mmol／L、（14．454-5．48）mmol／L、（11．43±3．25）％、（6．79±3．71）mg／L和（1．99±0．65）ng／m1]高于单纯2型糖尿病组[（7．25±0．64）mmol／L、（10．45±2．89）mmol／L、（8．56±1．58）％、（4．724-2．39）mg／L和（1．24±0．44）ng／ml，P〈0．05]。多因素相关分析示，Hs-CRP、TNF．仅和HbAlc是2型糖尿病合并大血管病变的相关危险因素。结论免疫炎性反应参与了2型糖尿病大血管病变的发生发展，而Hs-CRP、TNF-仅及HbAlc是2型糖尿病合并大血管病变的相关危险因素。

Objective To investigate the effect of immunological and inflammatory reactions on type 2 diabetic macrovascular disease. Methods 120 patients with type 2 diabetes mellitus and 60 health controls were enrolled in this study. The patients were divided into two sub - groups, type 2 diabetes melli- tus group and type 2 diabetic macrovascular disease group. The markers of immunological and inflammatoryreactions were detected, and the main associated factors were collected and analyzed by one -way ANOVA and logistic regression. Results The level of FBG, PPG, HbAlc, Hs-CRP and TNF-oL [ （9.86 ± 1.79） mmol/L, （ 14.45 ± 5.48 ） mmol/L, （ 11.43 -± 3.25 ） %, （6. 79 ± 3.71 ） mg/L , （ 1.99 ± 0. 65 ） ng/ml] in the group of type 2 diabetic macrovascular disease group were higher than type 2 diabetes mellitus group [ （7.25 ± O. 64 ） mmol/L, （ 10. 45 ± 2. 89 ） mmol/L, （ 8. 56 ± 1.58 ） %, （ 4. 72 ± 2. 39 ） mg/L, （ 1.24 ± 0. 44 ） ng/ml, P 〈 0. 05 ]. The risk factors in type 2 diabetic macrovascular disease were TNF-o±, Hs-CRP and HbA1 c. Conclusions Immunological and inflammatory reactions play a key role in type 2 diabetic macro- vascular disease.