摘要
目的观察免疫炎性反应标志物在2型糖尿病大血管病变患者的表达及相关性。方法收集本院住院治疗120例2型糖尿病患者及60例正常体检者的病史和临床生化资料,2型糖尿病患者根据有无大血管病变分成两组,单纯2型糖尿病组与2型糖尿病大血管病变组。ELISA法分别测定两组患者的免疫炎性反应标记物IL-1B、TNF-仅及Hs-CRP。分析免疫炎性反应与2型糖尿病大血管病变之间的关系。结果2型糖尿病大血管病变组患者血FBG、PPG、HbAlc、Hs-CRP及TNF-a水平[(9.86±1.79)mmol/L、(14.454-5.48)mmol/L、(11.43±3.25)%、(6.79±3.71)mg/L和(1.99±0.65)ng/m1]高于单纯2型糖尿病组[(7.25±0.64)mmol/L、(10.45±2.89)mmol/L、(8.56±1.58)%、(4.724-2.39)mg/L和(1.24±0.44)ng/ml,P〈0.05]。多因素相关分析示,Hs-CRP、TNF.仅和HbAlc是2型糖尿病合并大血管病变的相关危险因素。结论免疫炎性反应参与了2型糖尿病大血管病变的发生发展,而Hs-CRP、TNF-仅及HbAlc是2型糖尿病合并大血管病变的相关危险因素。
Objective To investigate the effect of immunological and inflammatory reactions on type 2 diabetic macrovascular disease. Methods 120 patients with type 2 diabetes mellitus and 60 health controls were enrolled in this study. The patients were divided into two sub - groups, type 2 diabetes melli- tus group and type 2 diabetic macrovascular disease group. The markers of immunological and inflammatoryreactions were detected, and the main associated factors were collected and analyzed by one -way ANOVA and logistic regression. Results The level of FBG, PPG, HbAlc, Hs-CRP and TNF-oL [ (9.86 ± 1.79) mmol/L, ( 14.45 ± 5.48 ) mmol/L, ( 11.43 -± 3.25 ) %, (6. 79 ± 3.71 ) mg/L , ( 1.99 ± 0. 65 ) ng/ml] in the group of type 2 diabetic macrovascular disease group were higher than type 2 diabetes mellitus group [ (7.25 ± O. 64 ) mmol/L, ( 10. 45 ± 2. 89 ) mmol/L, ( 8. 56 ± 1.58 ) %, ( 4. 72 ± 2. 39 ) mg/L, ( 1.24 ± 0. 44 ) ng/ml, P 〈 0. 05 ]. The risk factors in type 2 diabetic macrovascular disease were TNF-o±, Hs-CRP and HbA1 c. Conclusions Immunological and inflammatory reactions play a key role in type 2 diabetic macro- vascular disease.
出处
《中国医师杂志》
CAS
2012年第1期20-22,26,共4页
Journal of Chinese Physician
基金
上海市金山区卫生局课题