阿托伐他汀联合曲美他嗪治疗冠状动脉慢血流的临床研究

Treatment of coronary slow flow phenomenon with trimetazidine and atorvastatin

目的:通过对冠状动脉慢血流(CSF)患者临床资料进行分析,观察阿托伐他汀联合曲美他嗪(TMZ)对CSF的疗效。方法:64例经冠脉造影(CAG)诊断为CSF的患者,分成治疗组及对照组,患者知情同意,两组均给予硝酸酯类药物联合阿司匹林治疗,治疗组加用TMZ联合阿托伐他汀。观察治疗前后两组临床症状、运动负荷心电图(ECG)以及CAG复查冠脉血流速度的变化。结果:治疗组临床症状明显改善,有效率72%,对照组有效率44%(P<0.05);运动负荷ECG改善率治疗组75%,对照组47%(P<0.05);复查CAG显示冠脉血流帧计数,治疗组(20.54±4.37),对照组(25.43±5.55),组间比较差异有显著意义(P<0.01)。结论:TMZ联合他汀治疗对CSF有较好疗效。

Objective：To observe the therapeutic effect of trimetazidine（TMZ） and atorvastatin on coronary slow flow（CSF）by analysing the clinical data and CTFC of coronary arteriography（CAG）.Methods： The patients with CSF（n =64）were divided into the control group treated with the routine medications nitrate and aspirin,and the treatment group treated with TMZ and atorvastatin on the basis of the routine treatment of nitrate and aspirin.The changes of the clinical symptoms including ECG exercise test and coronary flow of CAG were observed before and after the treatment.Results： The symptoms of the patients were improved in both groups.The effective rate was 72.0% in the treatment group and 44.0% in the control group,there was a significant difference between the two groups（P0.05）.The improving rate of ECG was significantly higher in the treatment group than that of control group（P0.05）.The CTFC of the treatment group was significantly lower than that of the control group（20.5±4.37 vs 25.4±5.55,P0.01,respectively）.Conclusion：TMZ and atorvastatin on the basis of routine treatment of nitrate and aspirin have better therapeutic effect on CSF.