顶复门原虫入侵相关因子的研究进展

Invasion-associated Factors of Apicomplexa

顶复门原虫是一类专一性的细胞内寄生原虫,包括弓形虫(Toxoplasma gondii)、隐孢子虫(Cryptosporid-iumspp.)、疟原虫(Plasmodiumspp.)、巴贝斯虫(Babesiaspp.)及艾美耳球虫(Eimeriaspp.)等,是人和动物的重要病原。这类原虫具有相似的亚细胞结构和保守的入侵机制。研究结果表明,入侵过程是由大量的入侵相关蛋白分子所介导的,包括微线、棒状体及致密颗粒所分泌的相关蛋白等。随着生物信息学及分子生物学的发展,顶复门原虫入侵相关蛋白分子的研究资料也日益增多。笔者结合最近几年本课题组的研究成果,综述了顶复门原虫入侵相关蛋白因子的最新进展。

Apicomplexa is a protozoan class of obligate intracellular parasites, including Toxo- plasma gondii, Cryptosporidium spp., Plasmodium spp., Babesia spp. and Eimeria spp., many of them are important pathogens to human and animal. They have conserved subcellular structures and invasion mechanism. The results of lots of researches demonstrate that the inva- sion mechanisms are mediated by many invasion-associated factors, including the proteins secre- ted from micronemes, rhoptries and dense granules. The researches about these proteins make great progress with the development of bioinformatics and biotechnologies. In this paper, we re- view the latest progress of invasion-associated factor combining with our research results in recent years.