宫颈细胞学ASC-US与病理活检的对比观察

Comparison of cervical atypical squamous cells of undermined significances between cytology and biopsy

目的探讨宫颈活体组织病理检查与宫颈超薄液基细胞学检查在诊断意义未明的不典型鳞状细胞(ASC-US)中的应用价值。方法对308例用宫颈新柏氏液基细胞学检查(TCT)为ASC-US的患者,同时进行多点活体组织病理学检查和高危型HPV-DNA检测,将结果进行对比研究。结果 308例ASC-US患者中病理学检查,诊断宫颈上皮内瘤变(CIN)127例(41.2%),其中高级别CIN(CINⅡ～CINⅢ)33例(10.7%),炎症181例(59.7%);高危型HPV-DNA检测阳性116例(37.7%),其中CIN 81例(26.3%),高级别CIN 30例(9.7%)。结论对30～49岁年龄段女性宫颈筛查中发现的ASC-US病例和HPV-DNA检测中高危型HPV阳性者应做病理活检。

Objective To explore the clinical value of the cervical biopsy in the cases of atypacal squanous cell of under-mined significances（ASC-US） through cervical cytologic test.Methods 308 cases diagnosed as ASC-US through Thin-pre cytologic test（TCT） were undertaken multi-site biopsy and high risk HPV-DNA test,to conduct a comparative study on the results.Results In 308 cases with ASC-US,the results of multi-site biopsy were as follows： 127 cases were diagnosed as cervical intraepithelial neoplasia（CIN） which occupied 41.23% of the total cases（127/308）,in which 33 cases of high-grade CIN（CINⅡ-CINⅢ） 10.7%（33/308）,181 cases of inflammation,59.7%（181/308）;116 cases were detected positive through high risk HPV-DNA test,which occupied 37.7% of the total cases（116/308）,in which 81 cases of CIN,26.3%（81/308）,and 30 cases of high-grade CIN,9.7%（30/308）.Conclusion Patients in the age of 30 to 49 years with ASC-US by cervical cytological screening and high risk HPV patients detected positive in the HPV-DNA test should conduct cervical biopsy.