肥胖者内脂素基因多态性对糖脂代谢及运动减肥效果的影响

Effects of visfatin gene polymorphisms on glycolipid metabolism and exerciseinduced weight reduction in obesity

内脂素(visfatin),又被称为尼克酰胺磷酸核糖转移酶(nicotinamide phosphoribosyl transferase,NAMPT),是由脂肪组织分泌的细胞因子,在体内进行免疫调节,还可以作为NAMPT调节NAD+补救途径,同时也可影响糖脂代谢及运动减肥效果。本文旨在对肥胖者内脂素基因多态性与糖脂代谢及运动减肥效果的相关研究进行综述。

Visfatin, also named nicotinamide phosphoribosyl transferase （NAMPT）, is a cytokine secreted from adipose tissue. Visfatin can regulate immune action and is involved in the NAD＋ salvage pathway. In addition, recent researches have shown that visfatin helps the regulation of glucose and lipid metabolism, especially in exercise-induced weight reduction for obesity. The aim of this review is to provide an overview of the contribution of visfatin gene polymorphisms to glucose and lipid metabolism and exerciseinduced weight reduction in obesity.