血必净对重度颅脑外伤患者免疫系统的影响

Effect of xuebijing injection on the immune system in patients with severe traumatic brain injury

目的探讨早期应用血必净对重度颅脑外伤患者免疫系统的影响。方法重度颅脑外伤患者60例,随机均分为实验组和对照组,比较治疗前和治疗第4、8天外周血T淋巴细胞亚群CD3+、CD4+、CD8+及单核细胞HLA-DR抗原表达率、免疫球蛋白和补体的变化。结果治疗第4天,实验组CD4+高于对照组,CD8+低于对照组(P<0.05);第8天,实验组HLA-DR、CD3+、CD4+高于对照组,CD8+低于对照组(P<0.05)。治疗第4、8天免疫球蛋白IgA、IgG、IgM均稍高于对照组(P>0.05),补体C3明显低于对照组(P<0.05)。结论常规药物治疗基础上早期加用血必净能提高重度颅脑外伤患者的免疫功能,降低感染率,改善预后。

Objective To observe the effect of xuebijing injection on the immune system in patients with severe traumatic brain injury（STBI）. Methods Sixty patients with STBI were randomly divided into two groups of A（treated with conventional therapy and xuebijing） and B（treated with conventional therapy alone）. The expressions of peripheral T-lymphocyte subgroups, monocyte HLA-DR antigen and the contents of immunoglobulin and complement C3 and CA were measured before and on the 4th and 8th day during treatment. Results The expression of CIM＋ was higher, but CD8＋ was lower, in group A than those in group B on the 4th day during treatment （P〈0. 05）. HLA-DR,CD3^＋ ,CD4^＋were higher,but CI）8^＋ was lower,in group A than those in group B on the 8^＋ day during treatment（P〈0. 05）. Immunoglobulins of IgA, IgG, IgM in group A were slightly higher than those in group B on the 4th and 8th day during treatment （P〈0. 05 ）. Complement C3 was significantly lower in group A than that ink group B on the 4th and 8th day during treatment （P〈0. 05）. Conclusion On the basis of conventional therapy, additional use of xuebijing injection may improve the immune function in the patients with STBI, which is helpful in reducing infection and improving prognosis.