194例重症手足口病病原学检测及流行病学分析

Clinical epidemiological characteristics of 194 cases with severe hand-foot-mouth disease in Nanjing China

目的了解南京地区重症手足口病(HFMD)的流行病学规律,探索正确的应对措施。方法利用国家疾病监测网络直报信息系统,对本地区194例重症HFMD资料进行临床流行病学分析。结果 2009年南京地区重症HFMD的发病率为2.55/10万。其中,外来人口HFMD的发病率为3.13/10万,南京本地为2.20/10万。194例重症HFMD患儿中,3岁以下148例,占76.28%,男女比例为1.85∶1;通过对194例的病原学分析表明,肠道病毒71阳性63例(32.47%),COX A16阳性16例(8.25%)。结论 HFMD患儿,尤其是3岁以下的患儿高发,病程在5d以内发生。应控制感染源,加强HFMD监测,降低重症HFMD病死率。

Objective To analyze the epidemiological and clinical characteristics of children with severe hand foot mouth disease（HFMD） in Nanjing China. Methods Data of 194 cases with severe HFMD in 2009 were retrospectively analyzed. Results The incidence rate of severe HFMD in Nanjing China was 2.55/100 000, which was 3.13/100 000 for the migrants and 2.20/100 000 for the residents. Of 194 cases, 148 cases（76. 28%） were aged less than 3 years old, 126 cases were male and 68 cases were female with the ratio of male-to-female of 1.85 ： 1. Sixty-three（32. 47~） cases were found to be positive to Enterovirus71 and 16 cases（8. 25%） to COX A16. Conclusion Severe HFMD is frequently found in children less than 3 years old and the course of disease is usually within 5 days. It is important to Control the infection sources, strengthen the monitoring of HFMI）, and reduce the morbility of HFMD.