我国17家医院月经不调患者催乳素水平调查分析

Survey in prolactin levels of patients with irregular menstruation in 17 hospitals in China

目的调查我国17家医院妇科门诊月经不调患者中高催乳素血症的发生率。方法对17家医院妇科门诊因月经不调就诊的1,843例患者进行病史采集、体格检查及血清催乳素(PRL)水平检测;PRL水平≥3.41 nmol/L患者进行核磁共振成像(MRI)检查。结果经检测PRL水平升高者占21.00%(387/1,843);育龄期患者各年龄段高PRL血症发生率没有差异(P>0.05);进行MRI检查患者中30.12%(25/83)发现垂体瘤;PRL异常患者中20.69%(78/377)有自发或触发溢乳,与PRL正常者相比差异有统计学意义(P<0.05)。结论月经不调在妇科门诊中常见,对月经不调合并溢乳或不育的患者应注意筛查PRL水平。PRL水平升高者有必要行MRI检查。

Objective： To survey the prevalence of hyperprolactinemia in patients with irregular menstruation from 17 hospitals＇ clinics of China. Methods： A total of 1,843 patients with irregular menstruation were recruited for medical history tak- ing, physical examination and measuring serum prolactin （PRL） level. The magnetic resonance imaging （MRI） examination was implemented for patients with PRL≥3.41 nmol/L. Results： The PRL levels elevated in 21% （387/1,843） patients. The prevalence of hyperprolactinemia was no different among the patients in different age （P〉0.05）. Among the patients, 30.12% （25/83） patients were checked out with pituitary tumors, and 20.69% （78/377） patients with abnormal PRL level had spontaneous or trigger galactorrhea. There was a significant difference between the patients with normal and abnormal PRL level （P〈0.05）. Conclusions： Irregular menstruation is very common in the gynecology clinic. The PRL levels should be determined for the patients combined irregular menstruation with infertility or galactorrhea. MRI should be used to check the patients with elevated PRL level.