摘要
目的研究吸液缓溶性壬苯醇醚膜的急性毒性和致突变性,为评价安全性提供毒理学依据。方法使用昆明种清洁级小鼠进行急性经口毒性实验,小鼠骨髓嗜多染红细胞微核试验和小鼠精子畸形实验。结果对小鼠的急性经口毒性试验,LD_(50)>5,000mg/kg体重,属于实际无毒物。小鼠骨髓嗜多染红细胞微核和小鼠精子畸形率实验结果均为阴性,无致微核作用和无致精子畸形作用。结论吸液缓溶性壬苯醇醚膜无急性毒性作用,对体细胞和生殖细胞无致突变性。
Objective: To study the acute toxicity and mutagenicity of the imbibitlon slow solution nonoxynol-u (NP-9) membrane for evaluating its security. Methods: Toxicological properties of the membranes were evaluated by acute toxicity test, the micro- nucleus tests with bone marrow polychromatic erythrocyte and sperm abnormality tests in Kunming mice. Results: LD50 of the imbibition slow solution NP-9 membranes in Kunming mice was more than 5000 mg/kg, bw, and no toxic effects were observed. The results of micronucleus test and sperm abnormality test were negative. Conclusions: The imbibition slow solution NP-9 membrane had no acute toxicity and mutagenic action on somatic cell and germ cell.
出处
《生殖医学杂志》
CAS
2012年第1期55-58,共4页
Journal of Reproductive Medicine