摘要
目的:评价旋覆代赭汤加味防治肿瘤化疗引起的恶心、呕吐的疗效。方法:计算机检索中国期刊全文数据库和维普中文期刊数据库、万方学术期刊全文数据库2001-01-2010-12的相关文献,收集中药旋覆代赭汤预防肿瘤化疗引起的恶心、呕吐的随机对照试验(RCT)。按纳入排除标准筛选试验、评价研究质量、提取有效数据,并采用RevMan 5.0进行统计分析。结果:最终纳入12个RCTs,Meta分析显示,有效率(RR)为1.20,95%CI(1.13~1.27),差异有统计学意义,P<0.01。进行敏感性分析,结果稳定。漏斗图显示不对称,提示纳入评价的文献存在发表性偏倚。结论:中药旋覆代赭汤预防肿瘤化疗引起的恶心、呕吐有效,但由于本系统评价纳入研究的方法学质量较低,尚需开展更多设计合理、执行严格的多中心大样本且随访时间足够长的RCTs验证其疗效及安全性。
OBJECTIVE:To evaluate the efficacy of modified decoction of inulae and haematitium for prevention and curing of nausea and vomiting after chemotherapy.METHODS:CNKI,VIP,WanFang(2001 to 2010) were searched for randomized control trials about modified decoction of inulae and haematitium prevention and curing of nausea and vomiting after chemotherapy.Trial screening,quality assessment of included trials,and data extract were conducted.Statistical analysis was conductedby using RevMan 5.0 software.RESULTS:A total of 12 randomized controlled trials(RCTs)in the Chinese language were included.Meta analysis showed that the effective rate(RR=1.20,95%CI(1.13-1.27),P〈0.01),between the two groups was statistically significant.Sensitivity analysis showed the result was stable.Funnel plot was asymmetric that indicates publication bias.CONCLUSION:Modified decoction of inulae and haematitium is effective in prevention and curing of nausea and vomiting after chemotherapy,more large-scale multi-center randomized trials are needed.
出处
《中华肿瘤防治杂志》
CAS
2011年第23期1881-1884,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
旋覆代赭汤加味
中医药
化疗
呕吐
随机对照试验
META分析
modified decoction of Inulae and Haematitium
traditional Chinese medicine
chemotherapy
vomiting
randomized controlled trials
Meta-analyses