急性脑梗死患者血清YKL-40与脑梗死分型的相关性研究

Association between Serum YKL-40 in Patients with Acute Cerebral Infarction and Cerebral Infarction Classification

【目的】探讨血清炎性蛋白YKL-40与脑梗死临床分型和病因分型的关系,以指导临床诊治。【方法】应用ELISA方法检测91例急性脑梗死患者(发病48 h内)和34例健康对照者血清YKL-40的表达量,并对脑梗死患者进行CT分型、牛津郡社区卒中项目(OCSP)分型和治疗急性卒中实验(TOAST)分型,然后分析YKL-40表达量与各分型间的关系。【结果】急性脑梗死患者血清YKL-40表达量较健康对照组明显升高(P<0.001);脑梗死患者CT分型、OCSP分型及TOAST分型各亚型YKL-40表达量不同(P<0.001),其中大面积梗死组、TACI组及CE组血清YKL-40含量明显高于其它亚组。【结论】急性脑梗死患者血清YKL-40表达量明显升高,并且与病灶大小及病因有相关性,YKL-40可能对评估急性脑梗死患者的病情程度和临床预后具有提示作用,并对脑梗死的病因治疗具有指导作用。

[ Objective ] To determine and compare the level of serum YKL-40 at acute stage of cerebral infarction and to investigate the relationship among the levels of serum YKL-40 and different classification of acute ischemic stroke. [ Methods ] Serum YKL-40 levels were measured by enzyme immunoassay in 91 patients with cerebral infarction （within 48 h on admission） and 34 healthy controls. The relationship among the YKL-40 and clinical classification and the etiologic subtype of stroke were investigated. [Results]The levels of serum YKL-40 were significantly increased in patients with cerebral infarction than the normal control subjects（P 〈 0.00i ）. The levels of serum YKL-40 in large infarct group and TACI group and CE group were significantly higher than those in other groups according to different classification criteria. [Conclusions] Serum YKL-40 level elevated after isehemic stroke and was related to infarct size and the etiology. The serum YKL-40 might be a new biological marker to predict the severity and prognosis of ischemic stroke.