极端嗜盐古菌代谢网络研究

Research on metabolic network of extremely halophilic archaea

极端嗜盐古菌(extreInely thermophilic archaea)属于广域古菌界盐杆菌科,是古菌域中的典型生理类群,也是重要的极端微生物资源。文章主要对一种极端嗜盐古菌——盐沼盐杆菌(Halobacterium salinarum R1)——代谢网络的结构与功能进行了分析。对高质量盐沼盐杆菌代谢网络数据进行整理,构建了其中所有的代谢反应列表,并用代谢物图来表示。分析了该网络的功能模块和关键节点,并讨论了它们的生物学功能意义。

Extremely halophilic archaea belonging to the euryarchaeota halobium branch,it is a typical population in archaea,and very important to microbial resources.In this article,we mainly study the structure and function of metabolic network about one extremely halophilic archaea：Halobacterium salinarum Rl.We obtain a list of all metabolic reactions in Halobacterium salinarum R1 from published high-quality metabolic models,and represent it with metabolite graph.We analyze functional modules and hubs of the network,and discussed their biological signification.