活动期溃疡性结肠炎患者血清瘦素与ghrelin水平的临床分析

Serum leptin and ghrelin levels in patients with active ulcerative colitis

目的研究活动期溃疡性结肠炎（UC）患者血清瘦素及ghrelin水平变化情况及其临床意义。方法纳入54例活动期uc患者和25例正常对照，采用ELISA法检测所有入选者的血清瘦素及ghre-lin水平，并与UC患者的主要临床病理特征进行相关性分析。采用营养风险筛查2002（NRS2002）筛查活动期UC患者的营养风险。结果活动期UC患者的血清瘦素[（245．51±129．72）比（183．80-4-59．67）pg／ml，P：0．029]及ghrelin水平[（1477．964-501．86）比（1188．00±474．51）pg／ml，P=0．041]均显著高于正常对照组。UC患者血清瘦素（r=0．715，P=0．019）、ghrelin水平（r=0．667，P：0．027）与疾病严重程度相关，但与疾病临床类型、病变范围、内镜分级不相关（P均〉0．05）。有营养风险UC患者的血清瘦素[（332．82±172．92）比（194．15±49．71）pg／ml，P：0．026]及ghrelin水平[（1848．60±326．48）比（1259．93±459．24）pg／ml，P=0．021]均显著高于无营养风险uc患者。结论活动期uc患者血清瘦素及ghrelin水平增高，且与uc患者病情严重程度、营养风险相关。

Objective To investigate the change of serum leptin and ghrelin levels in patients with active ulcerative colitis （UC） and their clinical significance. Methods Fiftyfour patients with active UC and 25 normal controls were enrolled in this study, and serum levels of leptin and ghrelin were determined by enzymelinked immu nosorbent absorption. The correlations between serum leptin/ghrelin and the main clinicopathological features of pa tients with active UC were analyzed. The nutritional status of these patients were assessed by using the Nutritional Risk Screening 2002 （ NRS 2002）. Results The serum levels of leptin and ghrelin in patients with active UC were significantly higher than those in normal controls [ leptin： （245.51 ＋ 129.72 ） vs. （ 183. 80 ~ 59.67 ） pg/ml, P = 0. 029 ; ghrelin： （ 1477.96 ：t： 501.86） vs. （ 1188.00 _＋ 474.51 ） pg/ml, P = 0. 0d1 ] ; and both of them were corre lated with the disease severity （ leptin ： r = 0. 715, P = 0. 019 ; ghrelin ： r = 0. 667, P = O. 027 ）, but were not corre lated with the clinical type, the extent of lesion, and the endoscopic grading （all P 〉 0. 05）. In the UC patients with nutritional risk, the serum levels of leptin and ghrelin were also significantly higher than those in subjects without nutritionalrisk [leptin： （332.82_＋172.92） vs. （194.15_＋49.71） pg/ml, P=0.026; ghrelin： （1848.60_＋ 326.48） vs. （1259.93_＋459.24） pg/ml, P=O. 021]. Conclusion Patients with active UC have remarkably higher serum leptin and ghrelin levels, which is associated with the disease severity and the nutritional risk.