祖师麻不同提取部位的抗炎镇痛作用研究

Study on the Anti-inflammatory and Analgesic Activities of Extracts of Daphnes Cortex and Daphnes Folium

目的研究祖师麻叶与祖师麻皮抗炎镇痛作用。方法采用二甲苯所致小鼠耳肿胀和大鼠角叉菜胶足肿胀方法,研究祖师麻叶与祖师麻皮的抗炎作用;采用热板法、醋酸扭体法、光照甩尾法,研究祖师麻叶与祖师麻皮的镇痛作用。结果祖师麻叶与祖师麻皮对小鼠耳肿胀和大鼠足肿胀均有显著的抑制作用,能明显延长热板所致的小鼠舔后肢的时间,显著减少小鼠扭体反应的次数,显著提高光电引起的痛阈值。结论祖师麻叶与祖师麻皮均具有较强的抗炎、镇痛作用,祖师麻叶作用更强。

Objective To study the Anti-inflammatory and Analgesic Activities of extracts of Daphnes Cortex and Daphnes Folium. Methods The anti-inflammatory effect was investigated by xylene-induced mice auricular swelling test and carrageenin-induced rat paw edema. Methods of acetic acid-induced writhing, hot-plate test in mice and tail-flick test were used to study the analgesic effect of Daptmes Cortex and Daphnes FoliurrL Results Daphnes Cortex and Daphnes Folium could reduce mice auricula swelling and rats foot-plate swelling. They could prolong the leg-licking time in mice provoked by hot-plate and inhibit acetic acid-induced-wring reaction in mice.It could obvious to improving the value of pain threshold in mice. Conclusion Daphnes Cortex and Daphnes Folium have a significant role in anti-inflammatory and analgesia. Daphnes Folium is more potent.