摘要
目的探讨头孢曲松钠致过敏性休克的特点和规律,为临床安全用药提供参考。方法对2001～2010年国内公开发表文献中,有关头孢曲松钠致过敏性休克97例个案报道进行回顾性分析。结果有87.6%的过敏性休克发生在首次用药过程中,67.1%发生在用药后的10min内,死亡率达到18.6%;头孢曲松钠存在滥用和不合理用药等问题。结论应高度重视头孢曲松钠的合理使用,密切观察并及时抢救过敏性休克。
Objective To investigate the characteristics and regularities of anaphylactic shock induced by ceftriaxone sodium and provide the clinical reference of the drug safety.Methods Data were collected from domestic published literatures between 2001 to 2010 and 97 case reports of anaphylactic shock induced by Ceftriaxone Sodium were analyzed retrospectively.Results 87.6% of anaphylactic shock occurred in the first time use of Ceftriaxone Sodium and 67.1% of the reaction happened within 10 minutes of drug administration.The mortality rate of anaphylactic shock by Ceftriaxone Sodium were 18.6%.Clinical overuse and irrational combination of Ceftriaxone Sodium were found.Conclusion Rational use of Ceftriaxone Sodium is important.Close observation of drug reaction and well preparation for anaphylactic shock are recommended.
出处
《中国药物警戒》
2012年第3期178-180,共3页
Chinese Journal of Pharmacovigilance
关键词
头孢曲松钠
不良反应
过敏性休克
ceftriaxone sodium
adverse drug reaction
anaphylactic shock
