中医药对COPD患者肺组织缺氧诱导因子1α表达作用的研究进展

Research Progress of Expression of Hypoxia Inducible Factor-1α in Lung Tissue of Patients with COPD Treated by Traditional Chinese Medicine

缺氧诱导因子1α是在缺氧诱导的细胞核抽提物中发现的一种DNA结合蛋白,广泛存在于慢性缺氧细胞中。它在慢性阻塞性肺疾病中具有重要调节作用,中药干预HIF-l的表达有可能成为治疗COPD新的治疗方法。

Hypoxia-inducible factor-1α , a DNA-binding protein which was found in hypoxia- induced nuclear extracts, is widely present in chronic hypoxic cells. It plays an important regulatory role in chronic obstructive pulmonary disease.The Chinese intervention in HIF-1 expression may become a new way of COPD treatment.