抗CCP抗体联合RF检测类风湿性关节炎诊断试验Meta分析

Meta-analysis of diagnostic tests for rheumatoid arthritis with the screening methods of Anti-CCP and RF

目的通过诊断试验Meta分析,综合评价抗环瓜氨酸肽抗体(CCP)和类风湿因子(RF)联合诊断类风湿关节炎(RA)的效果。方法通过检索万方、维普、CNKI等数据库,获得有关抗CCP和RF联合诊断RA的文献,提取相关数据;采用SAS 8.02进行诊断试验Meta分析。结果抗CCP/RF并联的准确度为0.803,诊断优势比为16.590;抗CCP+RF串联的准确度为0.841,诊断优势比为27.781;两种联合诊断准确度比较,差异无统计学意义(P>0.05)。结论抗CCP和RF联合诊断效果较好,并联能够提高灵敏度,串联能够提高特异度,联合诊断对RA具有较高的诊断价值。

[Objective]To comprehensively evaluate the effect of anti-cyclic citrullinated peptide antibody（Anti-CCP） and rheumatoid factor（RF） on diagnosis of rheumatoid arthritis（RA） through Meta-analysis of diagnostic tests.[Methods]By search literature database such as Wangfang,Weipu,CNKI,the related literatures were obtained for data extraction.SAS 8.02 was adopted for Meta-analysis.[Results]Meta analysis indicated that the accuracy of anti-CCP/RF was 0.803 and diagnostic OR was 16.590.Those of anti-CCP＋RF screening method were 0.841 and 27.781 respectively.The difference of accuracy between 2 methods was not significant（P0.05）.[Conclusion]Both anti-CCP/RF and anti-CCP＋RF can be used in diagnosis of RA with good effect.Anti-CCP/RF can raise sensitivity,and Anti-CCP＋RF can heighten specificity.So this combination diagnosis has good value for RA diagnosis.