沙利多胺与叶酸偶联物的合成研究

Analysis on health examination results of staff in traffic management departments in Jiangmen city in 2010

本文报道了沙利多胺与叶酸偶联物的合成方法。以廉价易得的邻苯二甲酸酐和谷氨酰胺为原料通过酰化、环合反应得到沙利多胺,沙利多胺与37%甲醛溶液通过羟甲基化反应得到N-羟甲基沙利多胺,再与N-羟基琥珀酰亚胺（NHS）活化的叶酸通过偶联反应得到目标化合物。合成的关键中间体和目标化合物的物性与文献一致,其结构经核磁共振氢谱确认。

[Objective]To know the health status of outdoor staff in traffic management departments,provide the baseline data for health care of this population,as so to improve the health level and ensure the work quality.[Methods]In October 2010,1197 people in traffic management departments in Jiangmen received the health examination,and the results were analyzed.The health records of this population were established,and the health care guidance was performed.[Results]The main diseases with high detection rate and abnormal indexes were hyperlipidemia（33.8%）,fatty liver（31.1%）,Helicobacter pylori infection（24.1%）,hyperuricacidemia（16.9%）,hyperglycaemia（12.9%）,renal calculi（10.9%）,hypertension（7.7%）,gallbladder polyps（7.4%）,gallstones and choledocholithiasis（5.6%）.[Conclusion]The health situation of staff in traffic management departments is not good,and the prevalence of chronic non-communicable diseases is high.It is necessary to improve the health care in this population to promote the health situation.