对溴甲基苯甲酸甲酯的合成研究

Study on Synthesis of Methyl 4-(bromomethyl)benzoate

在四氯化碳溶液中,在光照条件下对甲基苯甲酸甲酯与N-溴代丁二酰亚胺(NBS)反应合成对溴甲基苯甲酸甲酯。通过正交实验得到对溴甲基苯甲酸甲酯的最佳合成条件为:NBS用量为对甲基苯甲酸甲酯的1.1倍,反应时间为4 h,过氧化苯甲酰为NBS的0.03倍,四氯化碳为对甲基苯甲酸甲酯的11倍,产率90.5%。

Methyl 4-（bromomethyl）benzoate was synthesized by the reaction of methyl 4-methylbenzoate with N-bromosuccinimide（NBS）.The optimum conditions of synthesizing the compound by orthogonal test obtained were that the molar ratio of N-bromosuccinimide to methyl 4-methylbenzoate was 1.1：1,reaction time was 4 h,the molar ratio of benzoyl peroxide to n-bromosuccinimide was 0.03：1,and the molar ratio of carbon tetrachloride to methyl 4-methylbenzoate was 11：1.Under the optimum synthetic conditions,the yield of the product was 90.5%.