血尿酸水平与缺血性脑卒中的相关性分析

A analysis on association of serum uric acid levels with ischemic stroke

目的探讨患者血清尿酸水平（BUA）与缺血性卒中的相关性。方法选择缺血性脑卒中患者78例为观察组，80名体检非卒中者为对照组，比较两组间BUA，研究BUA与患者病情及预后的关系。结果观察组患者血尿酸浓度（375．93±42．67）mol／L显著高于对照组（260．43±24．78）mol／L，P〈0．01；轻、中及重度病情患者血尿酸水平逐渐增高，两两比较差异均有统计学意义（P〈0．05）；血尿酸异常患者病情未愈及死亡38例，比例为59．3％，明显高于血尿酸正常者（P〈0．05）。结论血清尿酸水平与脑卒中患者病情及预后有密切关系。

Objective To investigate the relation between serum uric acid （ UA ） levels and ischaemic stroke. Methods 78 patients with ischaemic stroke were assigned to the study group and 80 healthy people were enrolled as control. Serum UA levels were compared between the two group. The association of UA with disease serverity and prognosis in patients was analyzed. Results UA levels were significantly higher in the study group than in the control group （ [375.93 ± 42.67]mol/L vs. [260.43 ± 24.78]mol/L, P〈 0.01 ）. Serum UA levels increased gradually in all the patients with slight, moderate, or severe isehemic stroke （ P〈 0.05 for all comparisons ）. The number of the patients who were not cured or were dead was greater in the patients with an elevated UA level than in those with a normal UA level （ P〈 0.05 ）. Conclusions Serum uric acid level was closely associated with the disease severity and prugnosis in patients with ischemic stroke.