中老年血清瘦素、脂联素、白介素-6及纤溶酶原激活物抑制物-1的流行病学调查

An epidemiologieal investigation on serum levels of leptin, adiponectin, interleukin-6 and plasminogen activator inhibitor-1 in middle aged and elderly people

目的对广州市中老年人血清瘦素（1eptin）、脂联素（adiponectin）、白介素-6（interleukin～6，IL-6）及纤溶酶原激活物抑制物-1（plasminogen activator inhibitor-1，PAI-1）进行流行病学调查。方法在广州市生物库第三期注册登记的10027名中老年人中随机抽取1996名中老年人进行问卷调查和健康体检。以酶联免疫吸附双抗夹心（ELISA）法测定leptin、adiponectin、IL-6、PAI-1。结果广州市中老年人leptin、adiponectin、IL-6、PAI-1分别为（10．46±9．75）μg，L、（9115．5±9812．91）μg/L、（13．13±6．50）μg／mL和（163．71±110．04）μg／L。校正年龄因素后，男、女性别间leptin、adiponectin、IL-6和PAI-1差异均有显著性（P〈0．05）。结论本次大样本的中老年leptin、adiponectin、IL-6、PAI-1的流行病学调查数据可靠，为后期的生活方式号漫性心、脑血管和代谢性疾病关系的研究和公共卫生干预提供了依据。

Objective To conduct an epidemiological investigation on leptin, adiponectin, interleukin-6 （ IL-6 ）, and plasminogen activator inhibitor-1 （ PAI-1 ） in the middle aged and elderly people in Guangzhou. Methods 1996 of 10 027 middle aged and elderly people registered at Guangzhou Database were randomly selected to be surveyed by questionnaires and to have physical examination. Levels of leptin, adiponectin, IL-6, and PAl-1 were determined by enzyme-linked immunosorbent assay （ELISA）. Results Leptin was （ 10.46 ± 9.75 ） μg/L, adiponectin was （ 9115.5 ± 9812.91 ） μg/L, IL-6 was （ 13.13 ± 6.50 ） pg/mL, and PAI-1 was （ 163.71 ± 110.04 ） μg/L in Guangzhou middle aged and elderly people. There were significant differences in levels of leptin, adiponectin, IL-6, and PAl-1 between male and female after age adjustment. Conclusions Reliable data of leptin, adiponectin, IL-6, and PAl- 1 in this large-scale epidemiological investigation provides support for the future research on the relationship between lifestyle and chronic cardiovascular, cardiocerebrovascular diseases and metabolic disorders and for public health interventions.