摘要
以腹腔注射大剂量氟化钠的方法,造成了授乳大鼠亚急性氟中毒动物模型。授乳早期中毒鼠垂体催乳素细胞的超微结构改变为:催乳素细胞的数量减少、体积变小,胞质内大的成熟分泌颗粒减少。有相当数量的催乳素细胞在超微结构上呈明显中毒损伤所见。这些结果提示:亚急性氟中毒可能主要表现为对催乳素细胞的直接毒害作用。
Animal model of subacute fluorosis in lactating rats was developed with injection of large dose NaF(IP).Ultrastructural changes of lactotrophs of experimental group were as follows:Quantity and volume of lactotrophs in experimental group was less than that in control and large mature secretory granulae decreased. Some lactotrophs showed remarkable ultrastructural changes which were caused by toxic substances. These results suggest that during subacute fluorosis fluoride might be directly toxic to lactotrophs.
出处
《中国地方病防治》
北大核心
1990年第6期328-329,共2页
Chinese Journal of Control of Endemic Diseases
基金
国家自然科学基金
