缺血缺氧性脑病新生儿血清皮质醇和血糖水平变化及临床意义

Changes and clinical significance of blood sugar and serum cortisol in neonates with hypoxic-ischemic eneephalopathy

目的探讨缺氧缺血性脑病（HIE）新生儿血清皮质醇（con）和血糖（GLU）水平的变化及其临床意义。方法对81例HIE新生儿和30例对照组进行GLU和COR检测并分析。结果HIE患儿除轻度组外，血清GLU水平均显著高于对照组（P〈0．05）；HIE患儿COR水平均明显高于对照组（P〈0．O）HIE程度越重，血清GLU和COR水平升高越明显；治疗后，HIE患儿血清COR含量呈下降趋势。结论临床治疗HIE过程中要严密观察GLU和COR的变化，严格控制葡萄糖输注的量及速度，应用糖皮质激素时严格掌握其适应证及剂量，以防止肾上腺皮质萎缩、高血糖的发生，以减少后遗症和HIE患儿死亡率。

Objective To investigate the changes and clinical significance of glucose （GLU） and serum cortical （COR） in neonates with hypoxic-ischemic encephalopathy （HIE）. Methods A total of 81 neonates with HIE and 30 healthy neonates were enrolled in this study for measurement of serum concen- trations of GLU and COR. Results The level of serum GLU in HIE groups except slight was higher than that of control group （P 〈 0.05）; the concentration of serum COR of neonate with HIE was significantly higher than that of control group （P〈 0.01）. The more severe degree of HIE was, the higher level of GLU and COR increased; after treatment, the concentration of serum COR of 81 neonates with hyperglycemia decreased. Conclusions Clinical treatment during the process of HIE need strict observation to the COR and GLU changes, strictly control the amount ofglucose infusion and speed. Use ofcorticosteroids strictly grasps its indication and dose, preventing adrenal cortical atrophy and high blood sugar from happening, in order to reduce sequels and HIE children mortality.