摘要
目的 研究老年性痴呆（AD）患者外周血中细胞因子浓度与认知功能的关系.方法 搜集认知功能正常者,轻度认知障碍（MCI）以及AD 患者,评估患者的认知功能,采集患者静脉血,利用酶联免疫吸附试验检测细胞因子（IL-β、IL-6 和IL-4、IL-10、IL-13）.结果 IL-1茁、IL-6、IL-10在3组之间差异有统计学意义（P＜0.05）,其中AD、MCI以及正常老年人差异具有统计学意义.结论 MCI患者作为AD 的临床前状态,认知功能的损害不同于AD,免疫状态也发生改变.
Objective To investigate the association of pro-inflammatory cytokines with cognitive function in elderly patients with dementia. Methods The cognitive function was assessed in patients with mild cognitive impairment （MCI） and Alzheimer＇s disease （AD）, subjects with normal cognitive function served as controls. Blood samples were collected from above subjects and serum IL-α, IL-β, IL-6, TNF-α levels were measured with enzyme-linked immunosorbent assay. Results There were significant differences in serum IL-1β, IL-6, IL-10 levels among three groups. The pro-inflammatory cytokine levels in AD and MCI patients were significantly higher than those in subjects with normal cognitive functions Conclusion MCI patients as a preclinical condition of AD also demonstrate changes of immune functions.
出处
《浙江医学》
CAS
2012年第3期159-161,172,共4页
Zhejiang Medical Journal
基金
浙江省医药卫生科技计划项目（2006A013）
浙江省老年医学重点学科群（2007zj008）
浙江省自然科学基金（Y2091289）
