依达拉奉对急性脑梗死患者血清超敏C反应蛋白的影响

Effects of Edaravone on High Sensitivity C-reactive Protein in Patients with Acute Cerebral Infarction

目的:通过观察急性脑梗死患者使用依达拉奉前后血清高敏感C反应蛋白(high sensitive C-reaction protein,hs-CRP)水平的变化,探讨依达拉奉在急性脑梗死患者治疗中的抗炎症作用。方法:选择200例急性脑梗死患者随机分为常规治疗组和依达拉奉组各100例,常规治疗组给予常规治疗,依达拉奉组在此基础上给予依达拉奉,观察评价2组患者的血清hs-CRP浓度变化、神经功能改善情况。结果:两组hs-CRP水平在梗死后7d最高,随后逐渐降低。依达拉奉组在治疗前、治疗后14d血清hs-CRP浓度和治疗前、治疗后7d的神经功能缺损总分与常规组比较差异无统计学意义(P>0.05),治疗后7d依达拉奉组hs-CRP水平低于常规组(P<0.05),14d依达拉奉组神经功能缺损总分与常规组比较,差异有统计学意义(P<0.01)。结论:依达拉奉在急性脑梗死患者的治疗中可以降低患者hs-CRP水平,并有助于ACI患者的神经功能恢复。

Objective. Through the observation of edaravone in acute cerebral infarction patients before and after the use of serum high sensitive C reactive protein （ high sensitive C-reaction protein, hs-CRP ） levels, of edaravone in acute cerebral infarction patients with the treatment of the anti-inflammatory effect. Methods：200 patients with acute cerebral infarction were randomly divided into conventional treatment group and edaravone group with 100 cases in each group, the conventional treatment group received routine treat- ment, edaravone group based on the evaluation of edaravone, observe 2 groups of patients with serum hs- CRP concentration change, nerve function improvement. Results： Two groups of hs-CRP levels in infarction after 7d is the highest, then reduced gradually. Edaravone group before treatment, after treatment, serum concentration of hs-CRP and 14d before treatment, after treatment of 7D neural function defect score and the conventional group compare difference not to have statistical significance （P〉0. 05 ）, 7d after treatment of edaravone group hs-CRP levels lower than the conventional group （P〈0. 05 ）, 14d edaravone nervous func- tion defect score and the conventional group comparison of the differences were statistically significant （P〈 0.01 ）. Conclusion：Edaravone in acute cerebral infarction patients can reduce the hs-CRP levels of patients, and improve the neurological function of acute cerebral infarction.