神经型地方性克汀病皮肤粘液性水肿的组织化学及电镜研究

Histochemical and ultrastructural studies of cutaneous myxoedema of endemic neurogenic cretinism

本文对神经型地方性克汀病的皮肤进行了组化及电镜研究,并用甲低病人、病区及非病区正常人的皮肤做对照。发现神经型克汀病人的皮肤有轻度粘液性水肿,粘液中含有中性和酐性粘蛋白。酸性粘蛋白中含有硫酸化的粘蛋白。文中对粘液性水肿的发生机理进行了讨论,并对流行区少数正常人皮肤出现粘液性水肿的意义进行了探讨。

The skin of the back of the neck and of the forearm from 9 cases of endemicneurogenic cretinism,7 cases of hypothyroidism,9 cases of normal individualin endemic area and 5 cases of normal individual in non-endemic area werestudied by histochemical methods and electron microscopy.We found thatmyxoedema with acid and neutral mucoprotein exists even in the skin of endemicneurogenic cretinism.The main component of acid glycoprotein is sulfomucin.Theorigin of the mucin is thought to be secreted from fibroblasts。The significanceof occasional presence of mucin in the skin of the normal controls in endemicarea is discussed.