摘要
低硒可以导致心肌线粒体膜流动性降低,呼吸酶障碍。鉴于外源性锰对大鼠体内硒的拮抗作用,本文探讨了高锰对大鼠心肌线粒体膜流动性的影响。经腹腔给大鼠注射40mg/kg氯化锰五周,致使大鼠心肌锰含量增高,而硒含量降低,全血谷胱甘肽过氧化物酶活性呈进行性下降。锰组大鼠心肌线粒体荧光偏振度及微粘度明显高于对照组大鼠。结果表明,高锰可以使大鼠心肌线粒体膜流动性明显降低。
Low selenium can decrease the mobility of mitochondria membrane lipids inthe myocardium and cause injures on mitochondrial respiratory enzymes.Beca-use high manganese takes against part on selenium in rat,so the effects ofmanganese on the mobility of mitochodria membrane lipids were studied. Manganese dichoride(40mg/kg of MnCl_2·4H_2O)was administrated daily to 38rats for 35 days intraperitoneally.An obvious increase in manganese content andselenium levels was reduced in myocardium.Glutathione peroxidase activity inthe whole blood of manganese-treated rats was below the controls.The degree offluorescence polarization(P)of two groups(MnCl_2 and 0.9% NaCl)was respe-ctively 0.366±0.020;0.274±0.013(P<0.01).In Conclusion,high manganese can reduce selenium content in myocardium andactivity of glutathione peroxidase in whole blood and reduce the mobility ofmitochondria membrane lipids in myocardium of rats.
出处
《中国地方病学杂志》
CAS
CSCD
1990年第5期277-280,共4页
Chinese Jouranl of Endemiology
关键词
锰
硒
心肌
线粒体
膜流动性
manganese
selenium mitochondria mobility of membrane lipids