结直肠癌术后风险预测模型CCF-CCM的应用进展

Advances in application of Cleveland Clinic Foundation colorectal cancer model

目的了解结直肠癌术后风险预测模型CCF-CCM的应用进展情况。方法检索CCF-CCM相关文献,进行阅读分析。结果有2篇文献主要与CCF-CCM相关,一篇介绍CCF-CCM的发展,一篇对其进行评论。结论 CCF-CCM专为接受外科手术的结直肠癌患者提供风险评估,用以评估人群中30 d手术死亡风险,经内源性验证发现CCF-CCM准确度较好。但在CCF-CCM为患者提供有意义的信息前,还需要在各中心进行专业验证与校准。在多中心前瞻性研究结果出来之前,该模型还不能用于对患者结果和外科医生能力进行绝对性的测量。

[ Objective] To explore the application of the Cleveland Clinic Foundation colorectal cancer model （CCF-CCM）. [Methods] The articles relevant to the CCF-CCM were searched and reviewed. [Results] There were two papers mostly relevant to the CCF-CCM, one described the development of the CCF-CCM, while the other gave a comment on the accuracy of the CCF-CCM. [Conclusion] The CCF-CCM has been designed specifically for patients undergoing colorectal cancer surgery in order to predict the risk of 30 day operative mortality. It is founded that the CCF-CCM provides an accurate assessment of operative risk in col- orectal cancer the patients undergoing surgery at the Cleveland Cancer Clinic by internally validating. And this model needs to be specifically validated and calibrated by individual institutions before meaningful information can be obtained and offered to patients. Furthermore, it should not be used as an absolute measure of patient outcomes or a surgeon＇s competency until a prospective multieenter validation study is carried out.