慢性咳嗽患儿呼吸道高反应的危险因素

Risk Factors of Airway Hyperresponsiveness of Children with Chronic Cough

目的探讨慢性咳嗽患儿呼吸道高反应的危险因素,为儿童慢性咳嗽的诊治提供依据。方法选择2008年9月-2009年10月就诊于本院呼吸科门诊的慢性咳嗽患儿141例。男68例,女73例;年龄(6.56±1.89)岁。予问卷调查及采用Astograph法测定其呼吸道高反应性,对有关变量进行单因素分析,再将单因素分析有意义的变量进一步行Logistic逐步回归分析,应用STATA7.0统计软件进行统计学分析。结果慢性咳嗽呼吸道反应性测定结果:呼吸道高反应106例,呼吸道反应正常35例。单因素分析有统计学意义的因素:直系亲属哮喘史、特应性皮炎史和被动吸烟。Logistic逐步回归分析显示,慢性咳嗽呼吸道高反应的独立危险因素有直系亲属哮喘史(OR=4.91;95%CI:1.326～18.192)和特应性皮炎史(OR=0.26,95%CI:0.116～0.623)。结论直系亲属有哮喘史和患儿有特应性皮炎史是儿童慢性咳嗽呼吸道高反应的独立危险因素。

Objective To investigate the risk factors for airway hyperresponsiveness of children with chronic cough,in order to provide clues for early diagnosis and treatment. Methods One hundred and forty-one children [68 cases were male,73 cases were female;aged（6.56±1.89） years] with chronic cough,visited the Children′s Hospital Affiliated to Fudan University from Sep.2008 to Oct.2009,were enrolled.Airway responsiveness of them had been determined by astograph measurement,and questionnaire had been finished.Clinical data were analyzed with mono-factor analysis and stepwise multivariate Logistic regression analysis by STATA 7.0 software. Results One hundred and six cases were airway hyperresponsiveness and 35 cases were normal airway responsiveness.Mono-factor analysis revealed that 3 indexes were obviously significant（Pa〈0.05）,they were immediate family member history of asthma,atopic dermatitis and environmental tobacco smoke exposure.Immediate family member history of asthma（OR=4.91,95%CI：1.326-18.192） and atopic dermatitis（OR=0.26,95%CI： 0.116-0.623） were the independent risk factors for airway hyperresponsiveness. Conclusions Immediate family member history of asthma and atopic dermatitis are the independent risk factors for airway hyperresponsiveness of children with chronic cough.