清瘟败毒饮对脓毒症的疗效及对部分血清免疫学指标的影响

Effect of Qingwenbaiduyin on clinical effects of sepsis and mmunological parameters in serum

目的:观察中药复方清瘟败毒饮对脓毒症(气营两燔证)的临床疗效以及对部分血清免疫学指标的影响。方法:将49例脓毒症患者随机分为西医常规治疗加清瘟败毒饮组(治疗组)25例、西医常规治疗组(对照组)24例,观察疗程7d,分别比较治疗前后中医症状积分、APACHEⅡ评分以及治疗前后外周静脉血IgG、IgA、IgM、C3、CRP、TNF-α水平(值)的变化。结果:两组总疗效比较无差异,但治疗组临床控制率优于对照组(P<0.05);两组患者与本组治疗前比较,中医症状积分和APACHEⅡ评分分值均明显下降(P<0.05,P<0.01),但同期比较治疗组优于对照组(P<0.05);两组患者与本组治疗前比较,IgG、IgA、IgM、C3、CRP、TNF-α水平(值)均降低(P<0.05,P<0.01),但治疗组同期优于对照组(P<0.05)。结论:清瘟败毒饮能提高脓毒症的临床疗效,有抑制脓毒症患者过度免疫应答、减少过度免疫应答对机体自身的损害方面的作用。

Objective： To observe the clinical effects of Qingwenbaiduyin in the treatment of sepsis（vigorous heat at qi-blood phase）,and its effects on some immunological parameters in serum.Methods： 49 cases of sepsis were randomly assigned to treatment with conventional Western medicine plus Qingwenbaiduyin group（treatment group） in 25 cases,conventional Western medicine treatment group（control group） in 24 cases.They were observed 7 treatment days.And contrast the before and after treatment Chinese medicine symptom score,PACHE Ⅱ score and peripheral blood before and after treatment IgG,IgA,IgM,C3,CRP,TNF-α level（value） changes,respectively.Results： The total effect of the two groups showed no difference,but the treatment group clinical control is superior to the control group（P〈0.05）.After treatment,the two groups Chinese medicine symptom score and APACHE Ⅱ score were significantly decreased（P〈0.05）,but the treatment group is superior to the control group（P〈0.05）;two groups before and after treatment of patients with IgG,IgA,IgM,C3,CRP,TNF-α levels（values） were lower（P〈0.05,P〈0.01）,but treatment group is superior to the control group（P〈0.05）.Conclusion： Qingwenbaiduyin can improve the clinical efficacy of sepsis,inhibit excessive immuneresponse in patients with sepsis and reduce the damage due to excessive immune response.