期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Ezrin和Fascin在喉鳞状细胞癌组织中的表达及意义 被引量：3

Expression and significance of Ezrin and Fascin in human laryngeal squamous cell carcinoma
下载PDF
导出
摘要 目的探讨埃兹蛋白(Ezrin)和聚束蛋白(Fascin)在喉鳞状细胞癌组织中的表达及其临床意义。方法采用免疫组织化学方法检测Ezrin、Fascin在喉鳞状细胞癌及其癌旁正常组织中的表达。结果 Ezrin和Fascin在喉鳞状细胞癌组织中的表达均高于癌旁正常组织(P<0.05);Ezrin及Fascin的表达与喉鳞状细胞癌组织中的淋巴结转移、临床分期和病理分级相关(P<0.05),而与患者的年龄、性别无关(P>0.05);喉鳞状细胞癌组织中Ezrin的表达水平与Fascin表达水平的相关性未明确(P>0.05)。结论 Ezrin和Fascin的过度表达可能与喉鳞状细胞癌的发生、发展及转移有密切的关系,检测Ezrin及Fascin的表达可能成为判断喉鳞状细胞癌预后的新指标。 Objective To study the expression of Ezrin and Fascin in human laryngeal squamous cell carcinoma （LSCC） and their clinical significance. Methods The expression of Ezrin and Fascin in human LSCC （group A） and tumor-adjacent normal larynx tissue （group B） were detected by citric-SP-immunoehemical technique. Results The expression of Ezrin and Fascin was higher in the group A than that in the group B （P〈0.05）. The expression of Ezrin and Fascin was correlated with lymph node metastasis, clinical stage and pathologic stage, but not with age and sex. The expression of Ezrin was not clearly correlated to that of Fascin in the group A. Conclusion Ezrin and Fascin may be directly associated with arise, development and metastasis of LSCC. The united detection of Ezrin and Fascin may be a new index judging the prognosis of LSCC.
作者 孙静 田军 吴桂卿 陈琪 殷宪宝 任文静
机构地区 潍坊医学院耳鼻喉科教研室 潍坊市人民医院耳鼻喉科
出处 《现代医药卫生》 2012年第3期339-340,342,共3页 Journal of Modern Medicine & Health
关键词 喉鳞状细胞癌 EZRIN FASCIN 免疫组织化学 Laryngeal squamous cell carcinoma Ezrin Fasein Immunohistochemistry
分类号 R739.65 [医药卫生—肿瘤]
  • 相关文献

参考文献12

  • 1Hunter KW.Ezrin,a key component in tumor metastasis[J].Trends MolMed,2004,10(5):201-204.
  • 2Soumaoro LT,Uetake H,Higuchi T,et al.Cyclooxygenase-2 expression:asignificant prognostic indicator for patients with colorectal cancer[J].Clin Cancer Res,2004,10(24):8465-8471.
  • 3Masunaga R,Kohno H,Dhar DK,et al.Cyclooxygenase-2expression cor-relates with tumor neovascularization and prognosis in human colorectal carcinoma patients[J].Clin Cancer Res,2000,6(10):4064-4068.
  • 4Mathew J,Hines JE,Obafunwa JO,et al.CD44is expressed in hepatocel-lular carcinomas showing vascular invasion[J].J Pathol,1996,179(1):74-79.
  • 5Yu Y,Khan J,Khanna C,et al.Expression profiling identifies the cyto-skeletal organizer ezrin and the developmental homeoprotein Six-1as key metastatic regulators[J].Nat Med,2004,10(2):175-181.
  • 6Khanna C,Wan X,Bose S,et al.The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis[J].Nat Med,2004,10(2):182-186.
  • 7张伟,刘媛媛,徐东来,刘东威,张学义.E-cadherin和Ezrin在大肠癌组织中的表达及意义[J].中国实验诊断学,2010,14(4):563-566. 被引量：5
  • 8Martin TA,Harrison G,Mansel RE,et al.The role of the CD44/ezrin com-plex in cancer metastasis[J].Crit Rev Oncol Hematol,2003,46(2):165-186.
  • 9Mkitie T,Carpen O,Vaheri A,et al.Ezrin as a prognostic indicator and its relationship to tumor characteristics in uveal malignant melanoma[J].Invest Ophthalmol Vis Sci,2001,42(11):2442-2449.
  • 10Moilanen J,Lassus H,Leminen A,et al.Ezrin immunoreactivity in relation to survival in serous ovarian carcinoma patients [J].Gynecol Oncol,2003,90(2):273-281.

二级参考文献12

  • 1Hunter KW.Ezrin,a key component in tumor metastasis[J].Trends Mol Med,2004,10(5):201.
  • 2Dorudi S,Sheffield JP,Poulsom R,et al.E-cadherin expression in colorectal cancer.An immunocytochemical and in situ hybridization study[J].Am J Pathol,1993,142(4):981.
  • 3Mathew J,Hines J E,Obafunwa J O,et al.CD44 is expressed in hepatocellular carcinomas showing vascular invasion[J].J Pathol,1996,179(1):74.
  • 4Cavallaro U,Christofori G.Multitasking in tumor progression:signaling functions of cell adhesion molecules[J].Ann N Y Acad Sci,2004,1014(4):58.
  • 5Berx G,Staes K,van Hengel J,et al.Cloning and characterization?of the human invasion suppressor gene E-cadherin (CDH1)[J].Genomics,1995,26(2):281.
  • 6Kanazawa N,Oda T,Gunji N,et al.E-cadherin expression in the primary tumors and metastatic lymph nodes of poorly differentiated types of rectal cancer[J].Surg Today,2002,32(2):123.
  • 7Yu Y,Khan J,Khanna C,et al.Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein six-1 as key metastatic regulators[J].Nat Med,2004,10(2):175.
  • 8Khanna C,Wan X,Bose S,et al.The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis[J].Nat Med,2004,10(2):182.
  • 9Pujuguet P,Del Maestro L,Gautreau,A,et al.Ezrin Regulates E-Cadherin-dependent Adherens Junction Assembly through Rac1 Activation[J].Mol Biol Cell,2003,14(5):2181.
  • 10Bretscher A,Edwards K,Fehon RG.ERM proteins and merlin:integrators at the cell cortex[J].Nat Rev Mol Cell Biol,2002,3(8):586.

共引文献4

同被引文献42

引证文献3

二级引证文献4

现代医药卫生
2012年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部