孟鲁司特钠联合阿奇霉素治疗小儿支原体肺炎疗效观察

Clinical observation of effects of combination therapy of montelukast and azithromycin on treating mycoplasma pneumonia in children

目的探讨孟鲁司特钠联合阿奇霉素治疗小儿支原体肺炎的临床效果。方法将68例患儿随机分为实验组和对照组各34例,实验组在口服阿奇霉素基础上加孟鲁司特钠咀嚼片口服;对照组口服阿奇霉素,比较两组疗效。结果实验组症状缓解时间及体征恢复时间均较对照组明显缩短,差异有统计学意义(P<0.05),半年后随访,实验组复发率明显低于对照组,实验组仅1例发生皮疹,不良反应发生率为2.9%。结论孟鲁司特钠联合阿奇霉素治疗小儿支原体肺炎效果显著,症状、体征缓解快,复发率低,不良反应小,值得临床推广。

Objective To evaluate the clinical efficacy of combination therapy of montelukast and azithromycin on treating children mycoplasma pneumonia.Methods 68 children patients with mycoplasma pneumonia were randomly divided into the experimental and the control groups.The control group was treated with oral azithromycin and the experimental group was treated with oral montelukast on the basis of treatment in the control group.Results The course of both symptoms relieving and signs recovery was significantly shorter in the experimental group,compared with the control group.The recurrence rate of the experimental group was significantly lower than that of the control group after six months follow-up.1 case of rash was observed in the experimental group,and the incidence of adverse reactions was 2.9%.Conclusion The combination therapy of montelukast and azithromycin is effective to treat mycoplasma pneumonia in children.The therapy can shorten the course of disease and reduce the rate of recurrence with low incidence of adverse reactions.The combination therapy of montelukast and azithromycin is worthy of being recommended for clinical application.