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氯沙坦对高血压合并2型糖尿病患者尿微量清蛋白的影响

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摘要 目的观察氯沙坦对高血压合并2型糖尿病患者尿微量清蛋白的影响。方法选择高血压合并2型糖尿病患者76例,随机分成对照组、治疗组;对照组采用综合疗法,治疗组在对照组治疗基础上加用氯沙坦50~100 mg,1次/天,观察治疗6个月前后的尿微量清蛋白、左心室质量指数的改变。结果治疗组较对照组能降低尿微量清蛋白的排泄,减轻心肌肥厚,两组比较差异均有统计学意义(P<0.05)。结论氯沙坦对高血压合并2型糖尿病患者的肾脏、心脏有保护作用。
作者 李小林
机构地区 海安隆政医院
出处 《现代医药卫生》 2012年第4期538-539,共2页 Journal of Modern Medicine & Health
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  • 1谢迪,张训.血管紧张素转化酶抑制剂与血管紧张素受体拮抗剂在慢性肾脏疾病治疗中的应用[J].国外医学(泌尿系统分册),2004,24(4):549-552. 被引量:16
  • 2[1]Remuzzi G,Ruggenenti P,Benigni A.Understarding the nature of renal disease progression[J].Kidneg Int,1997,51:1-15.
  • 3[2]Wang SL,Head J,Stevens L,et al.The world Health Organization Muhinational Study Group:Excess mortality and its relation tO hypertension and proteinuria in diabetic patients.the World Health Organization Multinational Study of Vascular Disease in Diabetes[J].Diabetes Care,1996,19:305-312.
  • 4[3]Iino Y,Hayashi M,Kawamura T,et al.Renoprotective effect of losartan in comparison to amlodipine in patients with chronic kidney disease and hypertensiona report of the Japanese losartan therapy intended for the global renal protection in hypertensive patients(JLIGHT)study[J].Hypertens Res,2004,27:21-30.
  • 5[4]Mackinnon M,Shurraw S,Akbari A,et al.Combination therapy with an angiotensin receptor blocker and an ACE inhibitor in proteinuric renal disease:a systematic review of the efficacy and safety data[J].Am J Kidney Dis,2006,48:8-20(Review).
  • 6[5]Horita Y,Tadokoro M,Taura K,et al.Low-dose combination therapy with temocapril and 10sartan reduces proteinuria in normatensive patients with immunoglobulin a nephropathy[J].Hypertens Res,2004,27:963-970.
  • 7Liu BC,Sun J,Chen Q,et al.Role of connective tissue growth factor in mediating hypertrophy of human proximal tubular cells induced by angiotensin Ⅱ[J].Am J Nephrol,2003,23(6):429.
  • 8Twigg SM,Chen MM,Joly AH,et al.Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein 2)in human fibroblasts:a potential mechanism for expansion of excellular matrix in diabetes mellitus[J].Endocrinology,2001,142(6):1 760.
  • 9Tang WW,Van CY,Qi M.Myofibroblast and al collagen expression in esperimental tubulointerstitial nephritis[J].Kidney Int,1997,51(2):926.
  • 10Chen MM,Lam A,Abraham JA,et al.CTGF expression is induced by TGF-beta incardiac myocytes:a potential role in heart fibrosis[J].J Mol Cell Cardiol,2000,32(3):1 805.

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