微波辐射制备羟丙基壳聚糖的研究

Synthesis of O-(hydroxyl isopropyl) Chitosan Assisted with Microwave Irradiation

在微波辐射下,以环氧丙烷为改性剂,四甲基碘化铵为催化剂合成羟丙基壳聚糖。探讨了微波处理时间、微波辐射功率、催化剂用量、反应物配比诸因素对产物产率和取代度的影响。实验结果表明,合成羟丙基壳聚糖的最佳反应条件为微波辐射功率为140 W,微波处理时间为2 h,催化剂用量为5%,m(壳聚糖)/V(环氧丙烷)=1∶10,产率为68.43%。

O-（hydroxyl isopropyl） chitosan was synthesized from chitosan and 1,2-epoxypropane in the presence of ammonium iodide assisted with microwave irradiation. The factors influencing the synthesis were discussed. The optimum reaction conditions were determined as follows： the ratio of chitosan to 1,2-epoxypropane of 1·10 （mg/mL）, the ratio ofchitosan to catalyst of 1 ·0.05（mg/mg）, the microwave power of 140 W and the microwave irradiating time of 2 h, under which the yield of o-（hydroxyl isopropyl） chitosan was 68.43 %.