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ZEB基因在肿瘤发生发展中的作用 被引量：5

Role of zinc finger E-box binding homeobox in the tumorigenesis and development
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摘要 E盒结合锌指蛋白(zinc finger E-box binding homeobox,ZEB)是重要的细胞核转录因子之一,在肿瘤发生发展中发挥重要的作用。通过介导肿瘤细胞的黏附性、细胞极性、细胞凋亡,调控原癌基因和维持微环境等过程,促进肿瘤的发生及发展。在肿瘤治疗中可能成为一个新的靶向基因。 Zinc finger E-box binding homeobox （ZEB） is one of the important nuclear transcription factors, and plays an important role in the occurrence and development of tumors. It promotes tumorigenesis and development by mediating tumor cell adhesion, microenvironment. ZEB is expected cell polarity, apoptosis, and by regulating oncogenes and maintaining the to be the target of tumor for therapy.
作者 刘雪咏 张声
机构地区 福建医科大学第一临床医学院病理科
出处 《国际病理科学与临床杂志》 CAS 2012年第1期69-73,共5页 Journal of International Pathology and Clinical Medicine
基金 福建医科大学第一临床医学院学科带头人培养对象专项基金(JXK200724)~~
关键词 E盒结合锌指蛋白 肿瘤 侵袭 转移 zinc finger E-box binding homeobox tumor invasiveness metastasis
分类号 R730.2 [医药卫生—肿瘤]
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参考文献27

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同被引文献64

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引证文献5

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国际病理科学与临床杂志
2012年 第1期

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