表皮生长因子受体与肺泡上皮不典型腺瘤样增生的关系

Epidermal growth factor receptor and alveolar epithelial atypical adenomatous hyperplasia

肺癌是人类常见的恶性肿瘤,肺腺癌是其主要类型之一。细支气管肺泡癌(bronchioloalveolar lung carcinoma,BAC)是肺腺癌的一个特殊类型。肺泡上皮不典型腺瘤样增生(atypical adenomatous hyperplasia,AAH)可能是BAC或腺癌的癌前病变,甚至是其早期癌。表皮生长因子受体(epidermal growth factor receptor,EGFR)的过表达和(或)突变与肺癌尤其是非小细胞肺癌(non-small-cell lung cancer,NSCLC)的发生、发展、侵袭和转移等密切相关。

Lung cancer is a common malignant tumor and lung adenocarcinoma is the main type of it. Bronchioloalveolar lung carcinoma （BAC） is a special type of lung adenocarcinoma. Research indicates that alveolar epithelial atypical adenomatous hyperplasia （AAH） in BAC or adenocarcinoma may be a precancerous lesion, even in the eady stage of cancer. Overexpression and/or mutatioin of epidermal growth factor receptor （EGFR） is closely related to the occurrence, development, invasion and metastasis of lung cancer, especially in non-small-cell lung cancer （NSCLC）. But there are few studies reported about EGFR in the precancerous lesion of non-small-cell lung cancer.