摘要
目的观察中药复方黄萸方对实验性糖尿病大鼠微量白蛋白尿的疗效,及对足细胞的影响。方法采用高糖高脂喂饲加低剂量STZ诱导伴胰岛素抵抗的大鼠2型糖尿病,给予黄萸方治疗12周,观察血糖及尿微量白蛋白,采用透射电镜及图像分析技术,观察对足细胞形态的影响。结果黄萸方可降低血糖、减少尿微量白蛋白,同时可改善足细胞损伤,疗效优于ARB。结论黄萸方可改善实验性大鼠2型糖尿病肾脏病变,主要是改善足细胞损伤,减少微量白蛋白尿。
Objective To explore the effect of Huang -Yu Fang （HYF） on urinary micro -albumin in experimental early diabetic rats, especially on podocyte damage. Methods Rats were fed a high glucose and high fat diet and given a low dose of STZ to develop type 2 diabetes with insulin resistance, and then treated with HYF 12 weeks. Blood glucose, urinary micro -albumin and other targets were measured, as well as the morphology of podoeytes were observed by transmission electron microscope. Results HYF could decrease blood glucose level, reduce urinary micro - albumin, and ameliorate the reduction of podocyte number and the podocytes fusion. These effects were better than ARB. Conclusion HYF has beneficial renoprotective effect on progression of type 2 diabetic nephropathy in rats, and the main effect is ameliorating the reduction of podoeyte number and the podocytes fusion, and reducing urinary micro -albuminuria.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2012年第2期299-301,共3页
Lishizhen Medicine and Materia Medica Research
基金
广东省自然科学基金(No.8151802001000010)
关键词
黄萸方
糖尿病肾病
微量白蛋白尿
胰岛素抵抗
足细胞
Huang - Yu Fang
Diabetic nephropathy
Microaibuminuria
Insulin resistance
Podocyte
