银屑病伴发高尿酸血症相关因素分析

Factors Related to Hyperuricemia in Patients with Psoriasis

目的探讨银屑病患者伴发高尿酸血症的相关因素。方法对167例住院银屑病患者的临床资料进行回顾性统计分析;对高尿酸血症组、尿酸正常组间进行单因素分析及多因素非条件Logistic回归分析。结果银屑病伴发高尿酸血症发生率为18.56%;高尿酸血症组与尿酸正常组比较,红皮病型损害、泛发性脓疱型损害、伴有脂肪肝及伴高血压病的差异均有统计学意义(P<0.05);脂肪肝、高血压病、红皮病型损害是影响银屑病患者发生高尿酸血症的重要因素,其优势比(OR)分别为5.571,3.611,2.884。泛发性脓疱型损害可能是银屑病伴发高尿酸血症的保护因素,OR值为0.082。结论银屑病患者伴发高尿酸血症可能与红皮病型损害、泛发性脓疱型损害、脂肪肝、高血压病有关;银屑病的特殊损害是影响血尿酸增高的重要因素。

Objective To determine the factors related to hyperuricemia in patients with psoriasis. Methods One hundred and sixty seven cases with psoriasis were analyzed retrospeetively. The factors related to hyperuricemia were determined by univa- riate and multivariate logistic regression. Results The incidence of hyperuricemia in the patients with psoriasis was 18.56%. There were statistically significant differenees between the hyperurieemia group and normal uric acid group with regard to erythro- derma, generalized pustula, fatty liver and hypertension （P 〈 0.05 ）. Fatty liver, hypertension and erythroderma were considered as essential factors in the occurrence of hyperurieemia,the odds ratios were 5. 571,3. 611 and 2.884 ,respectively. While the gener- alized pustula may be considered as a protection faetor, the odds ratio was 0.082. Conclusion The occurrenee of hyperuricemia in the patients with psoriasis may relate to erythroderma, generalized pustula, fatty liver and hypertension. Special types of psoria- sis may be considered as essential faetors in the occurrence of hyperuricemia.