急性冠状动脉综合征中基质金属蛋白酶-9与高敏C-反应蛋白的变化及复方丹参滴丸的治疗作用

Changes of MMP-9 and hs-CRP in acute coronary syndrome and the therapeutic effect of compound salvia pellet

目的探讨基质金属蛋白酶-9（MMP-9）与高敏C-反应蛋白（hs-CRP）在急性冠状动脉综合征中的意义及复方丹参滴丸的治疗作用。方法选择急性冠状动脉综合征患者60例，其中不稳定性心绞痛（UA）25例，急性心肌梗死（AMI）35例。将急性冠状动脉综合征患者随机分为常规治疗组和复方丹参滴丸治疗组，每组30例，另设健康对照组30例。入院后24h内及治疗12周后，分别采用ELISA法检测患者血清hs-CRP和MMPO水平。结果与正常对照组比较，常规治疗组患者血清hs—CRP、MMP-9随病情的加重而升高，差异有统计学意义（P〈0．05）；经复方丹参治疗组较常规治疗组血清hs-CRP和MMP-9明显降低，差异有统计学意义（P〈0．05）。结论急性冠状动脉综合征患者血清hs-CRP和MMP-9明显增高，且与病情的严重程度密切相关，复方丹参滴丸可显著降低血清hs-CRP和MMP-9水平，并在消除冠状动脉炎症、稳定冠状动脉斑块方面有很好的作用。

Objective To investigate the changes of matrix metalloproteinase-9 （MMP-9） and high sensitivity C-reactive protein（hs-CRP） in patients with acute coronary syndrome and the therapeutic effect of compound salvia pellet. Methods There were 60 patients with acute coronary syndrome, including unstable angina （UA, 25 patients） and acute myocardial infarction （AMI, 35 cases）, which were randomly divided into two groups, the conventional treatment group （30 cases） and the compound salvia pellet treatment group （30 cases）, and 30 healthy people were choosed as the normal control group. The expression of the serum hs-CRP and MMP-9 were detected at 24 hours after admission and 12 weeks after treatment by the method of ELISA. Results Compared with normal control group, the expression levels of serum hs-CRP and MMP-9 of the conventional treatment group increased remarkably with the aggrava- tion of the disease （ P 〈 0.05 ） , and compared with conventional therapy group, the expression level of compound salvia pellettreatment group was lower, the difference was significant （P 〈 0.05 ）. Conclusions The expression of serum hs-CRP and MMP-9 increased remarkably in acute coronary syndrome, and the expression level is closely related to the severity of the disease. Compound salvia pellet can sig- nificantly reduce the expression level of serum hs-CRP and MMP-9, and it has a good effect on the elimination of coronary artery inflammation, and stabilize coronary plaque.