摘要
Chitosan/cyclodextrin/trisodium citrate（CS/CD/TSC） nanoparticles with ibuprofen（IBU） loaded were prepared via the ionic cross-linking method, with trisodium citrate selected as the cross-linking agent. The drug-loading capacity, particle size, zeta potential and surface morphology of the obtained nanoparticles were inves tigated. The results show a good drug-loading capacity. The prepared nanoparticles were spherical in shape with an average size of 293.7 nm and a zeta potential of ＋30.72 mV. The in vitro release studies show that the controlled re lease of IBU from the nanoparticles was followed. The drug release from CS/β-CD/TSC nanoparticles followed non-Fickian or anomalous diffusion.
Chitosan/cyclodextrin/trisodium citrate（CS/CD/TSC） nanoparticles with ibuprofen（IBU） loaded were prepared via the ionic cross-linking method, with trisodium citrate selected as the cross-linking agent. The drug-loading capacity, particle size, zeta potential and surface morphology of the obtained nanoparticles were inves tigated. The results show a good drug-loading capacity. The prepared nanoparticles were spherical in shape with an average size of 293.7 nm and a zeta potential of ＋30.72 mV. The in vitro release studies show that the controlled re lease of IBU from the nanoparticles was followed. The drug release from CS/β-CD/TSC nanoparticles followed non-Fickian or anomalous diffusion.
基金
Supported by the Key Scientific and Technological Projects of Chongqing Science and Technology Commission, China (No.CSTC2010AC5050)
the Chongqing University(China) Postgraduates’ Science and Innovation Fund (No.CDJXS10220008)
