人参皂苷Rg3抗肝癌作用机制的研究进展

Research Progress on Anti - hepatoma Mechanisms of Ginsenoside Rg3

目的:探讨人参皂苷Rg3抗肝癌作用机制的研究情况。方法:搜集近年来有关人参皂苷Rg3抗肝癌作用机制的文献并进行分析。结果:人参皂苷Rg3是从补益中药人参中提取的单体,其抗肝癌作用机制主要包括诱导肝癌细胞凋亡、抑制肝癌细胞增殖、抑制肝癌细胞侵袭和转移、抑制肝癌血管生成、逆转肝癌细胞多药耐药、与化疗联合的协同增效作用等。结论:人参皂苷Rg3具有抗肝癌作用,但其主要的作用通路和相关靶点还不够清晰,需要进一步的研究与探索。

Objective: To investigate the condition of ginsenoside Rg3 in anti-hepatoma mechanisms.Methods: To collect and analyze the published data of ginsenoside Rg3 on the study of anti-hepatoma mechanisms.Results: Ginsenoside Rg3 is a metamer which is extracted from the traditional chinese herb ginseng.It can induce the apoptosis of liver cancer cells,inhibit the proliferation,invasion,metastasis and formation of new blood vessels,reverse the multidrug resistance of liver cancer cells.Further more,the combination of Rg3 and chemotherapeutic agents can reduce the toxicity and increase therapeutic effects.Conclusion: Ginsenoside Rg3 has anti-hepatoma effects,but the main effect pathways and related targets are not yet clear.It needs to be further researched and explored.