水杨酸-g-壳聚糖衍生物对皮肤溃疡愈合作用的实验研究

Experimental Study on the Therapeutic Action of Salicylic Acid-g-chitosan Derivatives on Skin Scald

目的:观察水杨酸-g-壳聚糖对实验性小鼠烫伤创面愈合的影响。方法:将小鼠进行烫伤造模处理后,随机将其分为空白组、模型组、京万红组、水杨酸-g-壳聚糖组和溶剂组;通过用药前后小鼠的体征变化、皮肤溃疡疮面愈合情况及病理形态来观察和评价水杨酸-g-壳聚糖对创面的愈合作用。结果:水杨酸-g-壳聚糖对烫伤所致溃疡有明显的促进其愈合的作用,其疗效与京万红软膏相当甚至优于京万红。结论:水杨酸-g-壳聚糖可以作为抗溃疡药进一步研究。

Objective:To observe the effect of ortho-oxybenzoic acid-g-chitosan on healing of skin scald of experimental rats.Methods:The model of skin scald of rats was established,and then the rats were randomly divided into 4 groups,including blank group,model group,jingwanhong ointment group,ortho-oxybenzoic acid-g-chitosan group and solvent group.Observing and estimating the effect of healing of ortho-oxybenzoic acid-g-chitosan on scalded wound from the change of physical signs,the condition of wound healing and pathological form of rats before and after medication.Results:Ortho-oxybenzoic acid-g-chitosan has the obvious effect of accelerating wound healing on skin scald,and has the same and even better medical efficacy than jingwanhong ointment.Conclusion:Ortho-oxybenzoic acid-g-chitosan can be further studied as a antiulcer medicine.