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颞叶癫痫的病因及发病机制的研究进展 被引量：2

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摘要 颞叶癫痫（Temporallobeepilepsy，TLE）是主要的难治性癫痫类型之一，发病人数日益增多，但其病因未明、发病机制不清，根据近年来有关TLE病因及机制的各种相关研究，可以看出TLE实际上是一种伴或不伴基因表达模式改变的情况下，细胞膜由于神经传递和信号传导异常、
作者 邬刚 许虹
机构地区 昆明医学院第一附属医院
出处 《云南医药》 CAS 2012年第1期76-79,共4页 Medicine and Pharmacy of Yunnan
关键词 颞叶癫痫 病因 发病机制
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献22

  • 1MATHERN GW,ADELSON PD,CAHAN LD,et al.Hip-pocampal neuron damage in human epilepsy:Meyer'shypothesis revisited[J].Prog Brain Res,2002,135:237-251.
  • 2KALACHIKOV S,EVGRAFOV O,ROSS B,et al.Mutationsin LGI 1 cause autosomal-dominant partial epilepsy withauditory features[J].Nat Genet,2002,30(3):335-341.
  • 3SCHEFFER IE,PHILLIPS HA,O'BRIEN CE,et al.Familialpartial epilepsy with variable foci:a new partial epilepsysyndrome with suggestion of linkage to chromosome 2[J].Ann Neurol,1998,44(6):890-899.
  • 4XIONG L,LABUDA M,LI DS,et al.Mapping of a gene de-termining familial partial epilepsy with variable foci tochromosome 22q11-q12[J].Am J Hum Genet,1999,65(6):1698-1710.
  • 5KINTON L,JOHNSON MR,SMITH SJ,et al.Partial epilep-sy with pericentral spikes:a new familial epilepsy syndromewith evidence for linkage to chromosome 4p15[J].AnnNeurol,2002,51(6):740-749.
  • 6MANNA I,LABATE A,GAMBARDELLA A,et al.Serotonintransporter gene(5-Htt):association analysis with temporallobe epilepsy[J].Neurosci Lett,2007,42(1):52-56.
  • 7KANEMOTO K,KAWASAKI J,MIYAMOTO T,et al.Inter-leukin(IL)1β,IL-1α,and IL-l receptor antagonist genepolymorphisms in patients with temporal lobe epilepsy[J].Ann Neurol,2000,47(5):571-574.
  • 8DRESES-WERRINGLOER U,LAMBERT JC,VINGT-DEUX V,et al.A polymorphism in CALHM1 inquencesCa2+Homeostasis,Aβlevels,and Alzheimer's DiseaseRisk[J].Cell,2008,133(7):1149-1161.
  • 9DELORENZO RJ,SUN DA,DESHPANDE LS.Cellularmechanisms underlying acquired epilepsy:the calcium hy-pothesis of the induction and maintenance of epilepsy[J].Pharmacol Ther,2005,105(3):229-266.
  • 10PALOP JJ,MUCKE L.Epilepsyand cognitive impairmentsin Alzheimer disease[J].Arch Neurol,2009,66(4):435-440.

二级参考文献20

  • 1[1]Gorm Danscher and J ens Zimmer. An important Timm sulphide silver method for light and electron microscopic localization of heavy metals in biological tissue[J]. Histochemistry, 1978, 55: 7- 40.
  • 2[2]Gregory L, Homes MS, Yehezkel B, et al. Mossy fiber sprouting after recurrent seizures during early development in rats[J]. J Comp Neurol, 1999, 404:537-553.
  • 3[3]Pierce JP, Milner, FA. Parallel increases in the synaptic and surface areas of mossy fiber terminals following seizure induction[J]. J Neurosi, 2001, 20: 77-86.
  • 4[4]Sutala Z,Acsady L,Kamondi A, et al. Network properties of dentate gyrus in epileptic rats with hilar neuron loss and granule cell axon reorganization [J]. J Neurophysiol, 1997, 77: 2685 - 2711.
  • 5[5]Mathern GW, BereramⅢ EH, Babb TL. In contrast to kindled seizures, the frequency of spontaneous epilepsy in the limbic status model correlates with greater aberrant fascia dentate excitatory and inhibitory axon sprouting and increased staining for NMDA, AMPA and GABA receptors [J]. Neuroscicnc, 1999, 35:1003-1019.
  • 6[6]Zhang Xia, Cui Sbu-Sen, Amy E, et al. Relations between brain pathlogy and temporal lobe epilepsy[J]. J Neurosci, 2002, 22: 6052- 6061.
  • 7Wang WZ, Wu JZ, Wang DS, et al. The prevalence and treatment gap in epilepsy in China: an ILAE/IBE/WHO study [J]. Neurology, 2003, 60(9): 1544-5.
  • 8Birbeck GL. Epilepsy care in developing countries: part I of II[J]. Epilepsy Curr, 2010, 10(4): 75-9.
  • 9Heinzen EL, Yoon W, Weale ME, et al. Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer's disease [J]. Genome Biol, 2007, 8(3): R32.
  • 10Gribkoff VK. The therapeutic potential of neuronal KCNQ channel modulators[J]. Expert Opin Ther Targets, 2003, 7(6): 737-48.

共引文献6

同被引文献22

  • 1Sibbe M, H~ussler U, Dieni S, et al. Experimental epi|epsy affects notch signalling and the stem cell pool in the dentate gyrus [ J ]. Eur J Neurosci ,2012,36(12) :3643-3652.
  • 2Barkas L, Redhead E, Taylor M, et al. Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epi- lepsy [ J ]. Brain, 2012,135 : 2358-2374.
  • 3Gupta A, Elgammal FS,Proddutur A,et al. Decrease in tonic inhi- bition contributes to increase in dentate semilunar grant~le cell ex- citability afler brain injury [ J ]. J Neurosci, 2012, 32 (7) : 2523 -2537.
  • 4Supcun B, Ghadiri MK,Zeraati M, et al. The effects of tetanic stim- ulation on plasticity of remote synapses in the hippocampus-perirhi- hal cortex-amygdala network [J]. Synapse, 2012, 66 ( 11 ) : 965 -974.
  • 5Zhao S,Studer D,Graber W, et al. Fine structure of hippoeampal mossy fiber synapses following rapid high-pressure freezing [ J ]. Epitepsia,2012,53 ( 1 ) :4-8.
  • 6Levin JR,Serrann G, Dingledine R. Reduction in delayed mortality and subtle improvement in retrograde memory peribrmance in pilo- carpine-treated mice with conditional neuronal deletion of cyelooxy- genase -2 gene [ J ]. Epilepsia, 2012,53 ( 8 ) : 1411 - 1420.
  • 7Soman S, Korah PK, Jayanarayanan S, et al. Oxidative stress in- duced NMDA receptor alteration leads to spatial memory deficits in temporal lobe epilepsy : ameliorative effects of Withania somnifera and Withanolide A [J]. Neuroehem Res, 2012, 37 ( 9 ) : 1915-1927.
  • 8Liu XB, Murray KD. Neuronal excitability and eaIcium/calm~du- lin-dependent protein kinase type 11: location, location, location [ J]. Epilepsia,2012,53 ( 1 ) :45-52.
  • 9左昕,潘奇波,林春辉.学习记忆中长时记忆形成的分子机制[J].海军医学杂志,2008,29(4):364-366. 被引量：6
  • 10左昕,邱太兴,潘奇波,林春晖.脑源性神经营养因子在学习记忆中作用机制的研究进展[J].海军医学杂志,2009,30(3):271-273. 被引量：1

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云南医药
2012年 第1期

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