阻塞性睡眠呼吸暂停低通气综合征患者生活质量及情绪和抑郁探讨

Correlation study about quality of life with excessive daytime sleepiness and depression in patients with obstructive sleep apnea hypopnea syndrome

目的通过阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的健康相关生命质量(HRQoL)、日间过度嗜睡(EDS)、抑郁情绪等调查量表,研究OSAHS患者与上述量表之间的相关性。方法入组71例,其中41例OSAHS患者为患者组,30例正常人为对照组,使用健康调查量表(SF-36)评价生活质量,用Epworth嗜睡量表(ESS)评估EDS,Zung抑郁自评量表(SDS)评价抑郁情绪。结果患者组与对照组相比,其ESS评分明显升高(14.68±6.25)分vs(5.96±2.38)分(P<0.01)。其SF-36评分中有4个维度评分不同程度下降,以SF最为明显VT(59.15±22.82)分vs(80.33±11.66)分(P<0.01);SF(80.85±14.66)分vs(90.86±6.67)分(P<0.01);RE(76.59±15.67)分vs(92.50±6.12)分(P<0.01)。OSAHS患者组中ESS评分与SF-36评分中3个维度呈负相关(PF:r=-0.407,P<0.01;RP:r=-0.523,P<0.01;VT:r=-0.417,P<0.01),其SDS评分与SF-36评分中1个维度呈负相关(SF:r=-0.381,P<0.05)。结论 OSAHS患者的生活质量较正常人群下降,并且与日间过度嗜睡、抑郁情绪明显有关。

Objective To explore the correlation about the health-related quality of life（HRQoL） with excessive daytime sleepiness（EDS） and depression in patients with obstructive sleep apnea hypopnea syndrome（OSAHS） via different professional scale. Methods Overall 71 people were enrolled in the study（41 patients with OSAHS as case group and 30 normal people as control group）.They were measured for HRQoL by using the Medical Outcomes Study Short-Form 36 survey（SF-36）,for EDS by using the Epworth Sleepiness Scale（ESS）,and for depression by using the Zung self-rating depression scale（SDS）. Results The ESS score in OSAHS group was significantly higher than that of control group,（14.68±6.25） scores vs（5.96±2.38） scores（P0.01）.The SF-36 scores in OSAHS group were lower than those of control group in four domains to different extent.The most obvious was in the SF domain,VT（59.15±22.82） scores vs（80.33±11.66） scores（P0.01）;SF（80.85±14.66） scores vs（90.86±6.67） scores（P0.01）;RE（76.59±15.67） scores vs（92.50±6.12） scores（P0.01）.The ESS score in OSAHS group was significantly negatively correlated with the SF-36 scores in 3 domains（PF：r=-0.407,P0.01;RP：r=-0.523,P0.01;VT：r=-0.417,P0.01）.The SDS score was negatively correlated with the SF-36 score in one domain（SF：r=-0.381,P0.05）. Conclusion The HRQoL of OSAHS patients was lower compared with that of normal control people.The poorer HRQoL of patients with OSAHS was strongly correlated with the SDS and ESS score