高分辨磁共振成像对颈动脉粥样硬化斑块表面钙化与斑块稳定性关系研究

Correlated study on superficial calcification and stability of carotid atherosclerotic plaque using high resolution MRI

目的通过高分辨磁共振成像(MRI)多序列扫描,分析颈动脉粥样硬化斑块的表面钙化的形状、位置与斑块稳定性的关系。方法运用高分辨MRI多序列(3D-TOF、DIR T1WI、FSE T2WI、PDWI)对34例颈动脉斑块患者进行扫描,分析钙化类型和位置与斑块表面溃疡的关系。结果 87层表面钙化斑块,59层(67.8%)见斑块表面溃疡。按钙化类型和部位划分,64层为点状、弧形的不规则钙化,23层为大片状钙化;58层为边缘钙化,29层为中央钙化。不规则钙化组伴斑块表面溃疡的概率显著高于大片状钙化组;边缘钙化组较中央钙化组更易伴斑块表面溃疡。结论表面钙化是斑块不稳定的重要因素之一,容易导致斑块表面溃疡形成;表面钙化的类型、部位对斑块的稳定性有重要影响。

Objective To evaluate the relationship of the shape,location of superficial calcification with stability of carotid atherosclerotic plaque using high resolution magnetic resonance imaging（MRI）. Methyls High resolution MRI was performed in the carotid artery of 34 patients with four sequences,including 3D-TOF, DIR TIWI, FSE T2WI and PDWI. The shape, location of superficial calcification with surface ulcer of carotid atherosclerotic plaque were evaluated. Results Out of 87 slices of superficial calcification, 59 slices plaques （67.8%） showed surface ulcer. According to calcification type and locati0n,64 slices were irregular （dotted/arcuated） calcification type,23 slices patch type,58 slices marginal calcification type and 29 slices central calcification type. Irregular superficial calcification was found more frequently with surface ulcer than patch calcification type. Marginal calcification type had higher possibility of surface ulcer than central calcification type. Conclusion Superficial calcification is an important factor for instability of atherosclerotic carotid plaque, which easily brings about surface ulcer on the carotid atherosclerotic plaque. The shape and location of superficial calcification are important factors of instability for atherosclerotic carotid plaque.