盐酸沙拉沙星的急性毒性和对鸡实验性沙门氏菌病的药效

Studies on acute toxicity and efficacy of sarafloxacin against experimental salmonellosis in chicks:

研究了盐酸沙拉沙星对小白鼠急性毒性和对人工感染禽源沙门氏菌病的药效。急性毒性试验测得盐酸沙拉沙星经口染毒昆明种小白鼠ＬＤ５０ 大于５ ０００ ｍｇ／ｋｇ，经腹腔注射染毒ＬＤ５０ 为６７７－６ ｍｇ／ｋｇ。药敏试验测得盐酸沙拉沙星对禽源沙门氏菌Ｃ７９ － １３ 株抑菌圈为（２３．３ ±０ ．９６）ｍｍ ；体内试验中，盐酸沙拉沙星以２０，３５ ，５０ 和７５ ｍｇ／Ｌ混饮给药，连续用药５ ｄ ，对沙门氏菌Ｃ７９ － １３ 株感染雏鸡有较好的保护作用，保护率分别为９０ ．０ ％ ，８６ ．７％ ，９０．０ ％ 和１００ ．０ ％ ，诺氟沙星（１５０ ｍｇ／Ｌ） 对照组对雏鸡保护率为８３ ．７ ％ ，而感染不给药组雏鸡存活率为５６ ．７ ％ ，差异极显著（ Ｐ＜ ０ ．０１）。盐酸沙拉沙星２０，３５，５０ 和７５ ｍｇ／Ｌ饮水给药组雏鸡在感染沙门氏菌９ ｄ 内雏鸡的相对增重率分别为７４ ．８ ％ ，６９－３ ％ ，７４．１％ 和７９ ．８％ ，均显著高于阳性对照组（５３ ．４％ ） ，也略高于诺氟沙星对照组（６１－５％ ） 。

The acute LD 50 of sarafloxacin hydrochloride in mice was above 5 000 mg/kg by oral administration and 677.6 mg/kg by intraperitoneal injection.Results of the drug sensitivity test showed that inhibition zone of sarafloxacin hydrochloride was (23.3±0.96)mm against salmonella.The therapeutic trials of sarafloxacin hydrochloride (20,35,50,75 mg/L) and norfloxacin (150 mg/kg) were carried out in chicks by oral administration in drinking water for 5 successive days against experimental induced salmonellosis.The protective rates of the above drugs were 90.0%,86.7%,90.0%,100.0% and 83.7%,respectively,whereas the livability of salmonellosis infected but untreated group was 56.7% ( P <0.01).The relative weight gain rates of the sarafloxacin hydrochloride treated groups in 9 days after salmonellosis inoculation were 74.8%,69.3%,74.1% and 79.8%,respectively,all significantly ( P <0.05) higher than that of the positive control (53.4%),and also a little higher than that of norfloxacin treated group (61.5%).