环氧孕酮肟的合成及其抗菌活性

Synthesis and Antimicrobial Activities of Epoxyprogesterone Oxime

在55℃保温搅拌下,在乙醇介质中以环氧孕酮为原料与不同剂量的盐酸羟胺反应合成得到环氧孕酮-3-肟和环氧孕酮-3,20-二肟,产率分别为68.58%和55.96%,利用红外光谱(IR),紫外(UV),质谱(MS),核磁共振谱(NMR)以及元素分析等技术来表征其结构.抗菌实验结果证实,两种环氧孕酮肟产物对实验菌株均有明显的抑制和灭活作用,特别是对金黄色葡萄球25925株和鼠伤寒沙门菌50013株更为显著.

Epoxyprogesterone-3-oxime and epoxyprogesterone-3,20-dioxime were synthesized from the raw material of 16α,17α-epoxyprogesterone in ethanol medium with 16α,17α-epoxyprogesterone and different dosage of hydroxylamine hydrochloride respectively at 55 ℃ by way of stirrer,and their yields reached up to 68.58% and 55.96%.These two compound structures were characterized by IR,UV,MS,1H NMR,13C NMR,135° DEPT and elemental analysis.The results of the antimicrobial activities of epoxyprogesterone-3-oxime and epoxyprogesterone-3,20-dioxime inhibited the growth of testing bacterias and sterilized them especially against Staphylococcus aureus 25925 and Salmonella typhimurium 50013.