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HBx介导的促肝癌作用 被引量：1

HBx-Mediated Promoting Role in the Development of Hepatocellular Carcinoma
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摘要 乙型肝炎病毒(Hepatitis B virus,HBV)感染是诱发原发性肝癌的主要原因之一.HBV存在4个相互重叠的开放读码框:S,C,P和X区.其中X基因表达的蛋白HBx被认为是诱导肝癌发生的一种多功能致癌蛋白,它可以作用于众多信号通路及细胞因子从而诱发肝癌.本文根据最新的研究,选择其中p53和NF-κB两条信号通路及HBx与表观遗传修饰的相关性进行了探讨,目的在于部分揭示HBV感染诱发肝癌的发病机理. Hepatitis B virus（HBV）caused chronic liver infections is one of the major inducing factors of hepatocellular carcinoma（HCC）.The full length viral genome has four overlapping reading frames that consist of S,C,P and X.The X protein of hepatitis B virus（HBx）,encoded by the X gene,is a multifunctional protein.It influences a variety of signal transduction pathways and modulates several cytokines,leading to hepatocellular carcinoma.Basing upon the latest studies,this review focuses on the HBx mediated modulation of p53 and NF-κB signal pathway.Additionally,the association between the HBx and the epigenetic modification is discussed,in order to better understand how HBx promotes the development of hepatocellular carcinoma.
作者 穆敬芳 冯辉 胡康洪
机构地区 中国科学院武汉病毒研究所/病毒学国家重点实验室
出处 《武汉大学学报（理学版）》 CAS CSCD 北大核心 2012年第1期61-67,共7页 Journal of Wuhan University:Natural Science Edition
基金 国家自然科学基金(30870131) 国家"十一五"传染病重大专项基金(2008ZX10002-011 2008ZX10004-004)资助项目
关键词 乙型肝炎病毒(HBV) 肝癌(HCC) P53 NF-κB 表观遗传修饰 hepatitis B virus（HBV） hepatocellular carcinoma（HCC） p53 NF-κB epigenetic modification
分类号 Q344 [生物学—遗传学]
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参考文献10

  • 1Cheng A S,Chan H L,Leung W K,et al.Expression of HBx and COX-2in chronic hepatitis B,cirrhosis and hepatocellular carcinoma:Implication of HBx in upregulation of COX-2[J].Mod Pathol,2004,17(10):1169-1248.
  • 2Wong C M,Fan S T,Ng I O.Beta-catenin mutation and overexpression in hepatocellular carcinoma:Clini-copathologic and prognostic significance[J].Cancer,2001,92(1):136-145.
  • 3Jung J K,Kwun H J,Lee J O,et al.Hepatitis B vi-rus X protein differentially affects the ubiquitin-media-ted proteasomal degradation of beta-catenin depending on the status of cellular p53[J].J Gen Virol,2007,88(Pt8):2144-2198.
  • 4Jung J K,Arora P,Pagano J S,et al.Expression of DNA methyltransferase1is activated by hepatitis B vi-rus X protein via a regulatory circuit involving thep16INK4a-cyclin D1-CDK4/6-pRb-E2F1pathway[J].Cancer Res,2007,67(12):5771-5779.
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武汉大学学报（理学版）
2012年 第1期

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